Carbamic acid, [(1S,2E)-1-ethyl-1-(3-methoxyphenyl)-3-[(1S,2S,5R)-5-methyl-2-(1-meth ylethyl)cyclohexyl]-2-propenyl]-, 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2E)-1-ethyl-1-(3-methoxyphenyl)-3-[(1S,2S,5R)-5-methyl-2-(1-meth ylethyl)cyclohexyl]-2-propenyl]-, 9H-fluoren-9-ylmethyl ester
CAS No.:616867-39-1
Molecular Formula:C37H45NO3
Molecular Weight:551.769
Hs Code.:

Carbamic acid,
[(1S,2E)-1-ethyl-1-(3-methoxyphenyl)-3-[(1S,2S,5R)-5-methyl-2-(1-meth
ylethyl)cyclohexyl]-2-propenyl]-, 9H-fluoren-9-ylmethyl ester

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Chemical Property of Carbamic acid, [(1S,2E)-1-ethyl-1-(3-methoxyphenyl)-3-[(1S,2S,5R)-5-methyl-2-(1-meth ylethyl)cyclohexyl]-2-propenyl]-, 9H-fluoren-9-ylmethyl ester

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Technology Process of Carbamic acid, [(1S,2E)-1-ethyl-1-(3-methoxyphenyl)-3-[(1S,2S,5R)-5-methyl-2-(1-meth ylethyl)cyclohexyl]-2-propenyl]-, 9H-fluoren-9-ylmethyl ester

There total 12 articles about Carbamic acid, [(1S,2E)-1-ethyl-1-(3-methoxyphenyl)-3-[(1S,2S,5R)-5-methyl-2-(1-meth ylethyl)cyclohexyl]-2-propenyl]-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24324-17-2
9-Fluorenylmethanol

: 1-[(E)-(S)-1-Ethyl-1-isocyanato-3-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-allyl]-3-methoxy-benzene

: 616867-39-1
[(E)-(S)-1-Ethyl-3-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-1-(3-methoxy-phenyl)-allyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With titanium(IV) isopropylate; In benzene; at 110 ℃;
DOI:10.1021/ja037078a

Reference yield:

: (Z)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-(3-methoxy-phenyl)-but-2-ene-1,4-diol

: 616867-39-1
[(E)-(S)-1-Ethyl-3-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-1-(3-methoxy-phenyl)-allyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: imidazole / CH₂Cl₂ / 6 h / 20 °C

2.1: 84 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

3.1: 100 percent / TBAF / tetrahydrofuran / 20 °C

4.1: CuCN / tetrahydrofuran; diethyl ether / 0.42 h / -15 °C

4.2: 86 percent / tetrahydrofuran; diethyl ether / 20 °C

5.1: 88 percent / Jones reagent / acetone / 6 h / 0 °C

6.1: diphenylphosphoryl azide; Et₃N / toluene / 1 h / Heating

7.1: 43.3 mg / titanium tetraisopropoxide / benzene / 110 °C

With 1H-imidazole; titanium(IV) isopropylate; dmap; jones reagent; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; toluene; benzene; 6.1: Curtius rearrangement;
DOI:10.1021/ja037078a

Reference yield:

: 616867-19-7
(E)-(S)-2-Ethyl-4-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-2-(3-methoxy-phenyl)-but-3-en-1-ol

: 616867-39-1
[(E)-(S)-1-Ethyl-3-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-1-(3-methoxy-phenyl)-allyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Jones reagent / acetone / 6 h / 0 °C

2: diphenylphosphoryl azide; Et₃N / toluene / 1 h / Heating

3: 43.3 mg / titanium tetraisopropoxide / benzene / 110 °C

With titanium(IV) isopropylate; jones reagent; diphenylphosphoranyl azide; triethylamine; In acetone; toluene; benzene; 2: Curtius rearrangement;
DOI:10.1021/ja037078a