2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2R,6R,11R)-rel-

Base Information

Chemical Name:2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2R,6R,11R)-rel-
CAS No.:7346-09-0
Molecular Formula:C18H25 N O
Molecular Weight:271.403
Hs Code.:

Synonyms:2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2a,6a,11R*)-; (?à)-Cyclazocine; (?à)-cis-Cyclazocine; MCV 4510; NIH 7981; NSC 172134; dl-Cyclazocine

Suppliers and Price of 2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2R,6R,11R)-rel-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of 2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2R,6R,11R)-rel-

Chemical Property:

Boiling Point:399.2°Cat760mmHg
Flash Point:188.7°C
Density:1.123g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2R,6R,11R)-rel-

There total 2 articles about 2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2R,6R,11R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 52079-30-8
(+/-)-cis-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan

: 5911-08-0
chloro(cyclopropyl)methane

: 7346-09-0
(+/-)-cyclazocine

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 80 ℃; for 15h;
DOI:10.1080/00397919908086216

Reference yield: 36.0%

: 16603-67-1,16670-83-0,16670-84-1,16670-86-3,16671-00-4,16808-63-2,25144-77-8,25144-78-9,52079-30-8
(-)-cis-N-Normetazocine

: 7051-34-5
cyclopropylcarbinyl bromide

: 3572-80-3,7313-86-2,7313-87-3,7346-09-0,13517-64-1,21820-30-4,21820-35-9,63903-61-7
(-)-Cyclazocine

Guidance literature:: With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;
DOI:10.1002/jhet.5570270753

Reference yield:

: 7346-09-0
(+/-)-cyclazocine

: (+/-)-3-(cyclopropylmethyl)-N-(diphenylmethylene)-1,2,3,4,5,6-hexahydro-cis-6,11-dimethyl-2,6-methano-3-benzazocin-8-amine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: Pd(OAc)2; rac-2,2'-bis(diphenylamino)-1,1'-binaphthyl; cesium carbonate / 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane / tetrahydrofuran / 65 - 70 °C

With palladium diacetate; N,N,N′,N′-tetraphenyl-1,1′-binaphthalene-2,2′-diamine; caesium carbonate; triethylamine; [2.2.2]cryptande; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm049978n