2-hydroxyaklavinone

Base Information

• Chemical Name: 2-hydroxyaklavinone
• CAS No.: 79008-78-9
• Molecular Formula: C₂₂H₂₀O₉
• Molecular Weight: 428.395
• Mol file: 79008-78-9.mol

Synonyms:1-Naphthacenecarboxylicacid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,4,5,7,9-pentahydroxy-6,11-dioxo-, methylester, [1R-(1a,2b,4b)]-; 2-Hydroxyaklavinone; 58D

Chemical Property of 2-hydroxyaklavinone

Chemical Property:

• Vapor Pressure: 8.01E-23mmHg at 25°C
• Boiling Point: 737.3°C at 760 mmHg
• Flash Point: 261.2°C
• PSA: 161.59000
• Density: 1.593g/cm³
• LogP: 1.41360

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxyaklavinone

There total 2 articles about 2-hydroxyaklavinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-2-O-acetyl-2-hydroxyaklavinone (92882-50-3) → (+/-)-2-hydroxyaklavinone (79008-78-9,85233-34-7,92936-42-0)

Guidance literature:

With sodium methylate; In methanol; at 0 ℃; for 0.2h;

DOI:10.1016/S0040-4039(01)81382-4

Reference yield:

(1S,2S)-9-Acetoxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacene-1-carboxylic acid methyl ester (92838-41-0) → (+/-)-2-hydroxyaklavinone (79008-78-9,85233-34-7,92936-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Br₂, AIBN, 2) H₂O / 1) reflux, 1h, 2) THF, room temperature, 1h

2: 100 percent / NaOMe / methanol / 0.2 h / 0 °C

With 2,2'-azobis(isobutyronitrile); water; bromine; sodium methylate; In methanol;

DOI:10.1016/S0040-4039(01)81382-4

upstream raw materials:

(+/-)-2-O-acetyl-2-hydroxyaklavinone

(1S,2S)-9-Acetoxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacene-1-carboxylic acid methyl ester

Refernces