3-(Difluoromethyl)-2-methylaniline

Base Information

Chemical Name:3-(Difluoromethyl)-2-methylaniline
CAS No.:61708-25-6
Molecular Formula:C₈H₉F₂N
Molecular Weight:157.163
Hs Code.:
DSSTox Substance ID:DTXSID60708732
Wikidata:Q82643246

Synonyms:3-(Difluoromethyl)-2-methylaniline;61708-25-6;SCHEMBL11807994;DTXSID60708732;TQU0127;2-methyl-3-difluoromethyl aniline;2-Amino-6-(difluoromethyl)toluene;3-difluoromethy-2-methyl-1-aminobenzene;3-difluoromethyl-2-methyl-1-aminobenzene;F88668;EN300-6771378;A1-08509

Suppliers and Price of 3-(Difluoromethyl)-2-methylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-(Difluoromethyl)-2-methylaniline 95%
2.500g
$ 1898.00

Alichem
2-Amino-6-(difluoromethyl)toluene
250mg
$ 494.40

Alichem
2-Amino-6-(difluoromethyl)toluene
1g
$ 1564.50

Alichem
2-Amino-6-(difluoromethyl)toluene
500mg
$ 863.90

A1 Biochem Labs
3-(Difluoromethyl)-2-methylaniline 95%
1 g
$ 750.00

Total 4 raw suppliers

Chemical Property of 3-(Difluoromethyl)-2-methylaniline

Chemical Property:

PSA：26.02000
LogP:3.09600
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:157.07030562
Heavy Atom Count:11
Complexity:127

Purity/Quality:

99% ^*data from raw suppliers

3-(Difluoromethyl)-2-methylaniline 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC=C1N)C(F)F

Technology Process of 3-(Difluoromethyl)-2-methylaniline

There total 4 articles about 3-(Difluoromethyl)-2-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(difluoromethyl)-2-methyl-1-nitrobenzene

: 61708-25-6
3-(difluoromethyl)-2-methyl-1-aminobenzene

Guidance literature:: With platinum on activated charcoal; hydrogen; In methanol; at 35 ℃; for 8h;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 61708-25-6
3-(difluoromethyl)-2-methyl-1-aminobenzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 °C

1.2: 72 h / 20 °C / Cooling with ice

2.1: manganese(IV) oxide / chloroform / 5 h / Reflux

3.1: diethylamino-sulfur trifluoride / chloroform / 16 h / -78 - 20 °C

4.1: hydrogen; platinum on activated charcoal / methanol / 8 h / 35 °C

With manganese(IV) oxide; sodium tetrahydroborate; diethylamino-sulfur trifluoride; platinum on activated charcoal; hydrogen; In tetrahydrofuran; methanol; chloroform;

Reference yield:

: 23876-13-3
(2-methyl-3-nitrophenyl)methanol

: 61708-25-6
3-(difluoromethyl)-2-methyl-1-aminobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: manganese(IV) oxide / chloroform / 5 h / Reflux

2: diethylamino-sulfur trifluoride / chloroform / 16 h / -78 - 20 °C

3: hydrogen; platinum on activated charcoal / methanol / 8 h / 35 °C

With manganese(IV) oxide; diethylamino-sulfur trifluoride; platinum on activated charcoal; hydrogen; In methanol; chloroform;