Pyrazolo(1,5-a)quinoline, 4,5-dihydro-2-(3-methoxyphenyl)-

Base Information

Chemical Name:Pyrazolo(1,5-a)quinoline, 4,5-dihydro-2-(3-methoxyphenyl)-
CAS No.:60230-70-8
Molecular Formula:C18H16N2O
Molecular Weight:276.3324
Hs Code.:
DSSTox Substance ID:DTXSID70208975
Nikkaji Number:J66.498G
Wikidata:Q83083120

Synonyms:BRN 0670592;Pyrazolo(1,5-a)quinoline, 4,5-dihydro-2-(3-methoxyphenyl)-;4,5-Dihydro-2-(3-methoxyphenyl)pyrazolo(1,5-a)quinoline;60230-70-8;4,5-Dihydro-2-(3-methoxyphenyl)pyrazolo[1,5-a]quinoline;DTXSID70208975;LS-129329

Suppliers and Price of Pyrazolo(1,5-a)quinoline, 4,5-dihydro-2-(3-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of Pyrazolo(1,5-a)quinoline, 4,5-dihydro-2-(3-methoxyphenyl)-

Chemical Property:

Vapor Pressure:5.86E-08mmHg at 25°C
Boiling Point:452.8°Cat760mmHg
Flash Point:227.6°C
Density:1.2g/cm³
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:276.126263138
Heavy Atom Count:21
Complexity:361

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C2=NN3C(=C2)CCC4=CC=CC=C43

Technology Process of Pyrazolo(1,5-a)quinoline, 4,5-dihydro-2-(3-methoxyphenyl)-

There total 9 articles about Pyrazolo(1,5-a)quinoline, 4,5-dihydro-2-(3-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 60230-82-2
2-(3-Methoxy-phenyl)-4,5-dihydro-pyrazolo[1,5-a]quinoline-3-carboxylic acid

: 60230-70-8
2-(m-Anisyl)-4,5-dihydro-pyrazolo<1,5-a>-chinolin

Guidance literature:: In neat (no solvent); Heating;

Reference yield:

: 612-41-9
2-nitrocinnamic acid

: 60230-70-8
2-(m-Anisyl)-4,5-dihydro-pyrazolo<1,5-a>-chinolin

Guidance literature:: Multi-step reaction with 7 steps

1: H₂, 1percent aq. NaOH / Pd/C / H₂O / Ambient temperature

2: 1.) NaNO₂, HCl

3: 1.) SnCl₂, conc. HCl; 2.) 2.5percent HCl / 1.) 15 h; 2.) reflux, 5 min

4: p.toluenesulfonic acid / benzene / Heating

5: Na / various solvent(s) / Heating

6: 70 percent / NaOH / ethanol / Heating

7: 55 percent / neat (no solvent) / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; sodium; toluene-4-sulfonic acid; tin(ll) chloride; sodium nitrite; palladium on activated charcoal; In ethanol; water; benzene;

Reference yield:

: 60230-78-6
1-amino-3,4-dihydroquinoline-2(1H)-one

: 60230-70-8
2-(m-Anisyl)-4,5-dihydro-pyrazolo<1,5-a>-chinolin

Guidance literature:: Multi-step reaction with 4 steps

1: p.toluenesulfonic acid / benzene / Heating

2: Na / various solvent(s) / Heating

3: 70 percent / NaOH / ethanol / Heating

4: 55 percent / neat (no solvent) / Heating

With sodium hydroxide; sodium; toluene-4-sulfonic acid; In ethanol; benzene;