Antibiotic KA 6606IX

Base Information

• Chemical Name: Antibiotic KA 6606IX
• CAS No.: 81768-57-2
• Molecular Formula: C₁₄H₃₀N₄O₄
• Molecular Weight: 318.417
• Mol file: 81768-57-2.mol

Synonyms:

Chemical Property of Antibiotic KA 6606IX

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Antibiotic KA 6606IX

There total 1 articles about Antibiotic KA 6606IX which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sporaricin B hydroiodide (84278-40-0,89064-84-6) → 3-O-demethylsporaricin B (75106-35-3,75172-12-2,81768-57-2,81768-58-3,83648-60-6)

Guidance literature:

With hydrogen iodide; at 70 ℃; for 7h;

DOI:10.1016/0008-6215(82)84030-5

Reference yield: 97.0%

3-O-demethylsporaricin B (75106-35-3,75172-12-2,81768-57-2,81768-58-3,83648-60-6) + benzyl chloroformate (501-53-1,94274-21-2) → 1,4,2',6'-tetrakis-N-(benzyloxycarbonyl)-3-O-demethylsporaricin B (81090-87-1,81131-61-5)

Guidance literature:

With sodium carbonate; In methanol; water; for 3h;

DOI:10.1016/0008-6215(82)84030-5

Reference yield:

3-O-demethylsporaricin B (75106-35-3,75172-12-2,81768-57-2,81768-58-3,83648-60-6) → 3-O-(3-amino-2-hydoxypropyl)-3-O-demethylsporaricin A (84247-60-9,84278-44-4,86194-55-0,86195-12-2)

Guidance literature:

Multi-step reaction with 8 steps

1: 97 percent / Na₂CO₃ / methanol; H₂O / 3 h

2: 78 percent / 0.1M aq. Ba(OH)2 / dioxane / 1 h / 60 °C

3: 86 percent / BaO, Ba(OH)2*H₂O / dimethylformamide / 21 h / Ambient temperature

4: 0.34 aq. Ba(OH)2 / dioxane / 18 h / 60 °C

5: Et₃N / dioxane / 2 h / 90 °C

6: 77 percent / m-chloroperoxybenzoic acid / CHCl₃ / 16 h / Ambient temperature

7: 79 percent / NaN₃ / dimethylformamide / 16 h / 70 °C

8: 38 percent / H₂ / Pd black / acetic acid

With barium dihydroxide; sodium azide; hydrogen; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; barium(II) oxide; palladium; In 1,4-dioxane; methanol; chloroform; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/0008-6215(82)84030-5

upstream raw materials:

sporaricin B hydroiodide

Downstream raw materials:

1,4,2',6'-tetrakis-N-(benzyloxycarbonyl)-3-O-demethylsporaricin B

3-O-(3-amino-2-hydoxypropyl)-3-O-demethylsporaricin A

3-O-demethyl-3-O-(2,3-dihydroxypropyl)sporaricin A

3-O-(4-amino-2-hydroxybutyl)-3-O-demethylsporaricin A