4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine

Base Information

Chemical Name:4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine
CAS No.:61771-18-4
Molecular Formula:C21H26ClNO
Molecular Weight:343.89000
Hs Code.:2933990090

Synonyms:1H-Azepine,4-[1-(4-chlorophenyl)-1-phenylethoxy]hexahydro-1-methyl;

Suppliers and Price of 4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Methyl-4-[1-(4-chlorophenyl)-1-phenylethoxy)hexahydroazepine
25mg
$ 160.00

Total 9 raw suppliers

Chemical Property of 4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine

Chemical Property:

PSA：12.47000
LogP:5.04230

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl-4-[1-(4-chlorophenyl)-1-phenylethoxy)hexahydroazepine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-Methyl-4-[1-(4-chlorophenyl)-1-phenylethoxy)hexahydroazepine (Clemastine EP Impurity B) is an impurity in the synthesis of Clemastine Fumarate (C568500); a H1 histamine receptor antagonist and antihistaminic.

Technology Process of 4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine

There total 2 articles about 4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 59767-24-7
1-(4-chloro-phenyl)-1-phenyl-ethanol

: (-)-(S)-2-(2-chloroethyl)-1-methylpyrrolidine

: 61771-18-4
4-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-1-methyl-azepane

: 61826-31-1
(S)-2-(2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl)-1-methylpyrrolidine

: (S)-2-(2-[(1S)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl)-1-methylpyrrolidine

Guidance literature:: 1-(4-chloro-phenyl)-1-phenyl-ethanol; With sodium hydride; In toluene; mineral oil; for 3h; Reflux;

(-)-(S)-2-(2-chloroethyl)-1-methylpyrrolidine; In toluene; mineral oil; at 20 ℃; Reflux; Inert atmosphere;
DOI:10.1021/ol100627c