2-Amino-N-(8-benzyl-3-alpha-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide

Base Information

Chemical Name:2-Amino-N-(8-benzyl-3-alpha-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide
CAS No.:91595-94-7
Molecular Formula:C₂₀H₂₅N₅O₂
Molecular Weight:367.451
Hs Code.:
DSSTox Substance ID:DTXSID20919640
Wikidata:Q82892196

Synonyms:91595-94-7;2-Amino-N-(8-benzyl-3-alpha-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-amino-N-(8-benzyl-3-alpha-nortropanyl)-4-methoxy-;DTXSID20919640;N-(8-Benzyl-8-azabicyclo[3.2.1]octan-3-yl)-2-imino-4-methoxy-1,2-dihydropyrimidine-5-carboximidic acid

Suppliers and Price of 2-Amino-N-(8-benzyl-3-alpha-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Amino-N-(8-benzyl-3-alpha-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:367.20082506
Heavy Atom Count:27
Complexity:499

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=NC(=NC=C1C(=O)NC2CC3CCC(C2)N3CC4=CC=CC=C4)N
Isomeric SMILES:COC1=NC(=NC=C1C(=O)NC2C[C@H]3CC[C@@H](C2)N3CC4=CC=CC=C4)N

Technology Process of 2-Amino-N-(8-benzyl-3-alpha-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide

There total 3 articles about 2-Amino-N-(8-benzyl-3-alpha-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56880-18-3
(1R,3R,5S)-8-Benzyl-3-chloro-8-aza-bicyclo[3.2.1]octane

: 91595-94-7
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid ((1R,3R,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NaN₃ / ethanol; H₂O / 20 h / Heating

2: 81 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

3: 1.) NEt₃, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT

With lithium aluminium tetrahydride; sodium azide; chloroformic acid ethyl ester; triethylamine; In diethyl ether; ethanol; water;

Reference yield:

: (1R,5S)-3-Azido-8-benzyl-8-aza-bicyclo[3.2.1]octane

: 91595-94-7
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid ((1R,3R,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

2: 1.) NEt₃, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT

With lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine; In diethyl ether;

Reference yield:

: 76272-35-0
3 α-amino-8-phenylmethyl-8-azabicyclo<3,2,1>octane

: 72418-38-3
2-amino-4-methoxy-5-pyrimidinyl carboxylic acid

: 91595-94-7
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid ((1R,3R,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT;