Benzenemethanol, a-2-propynyl-, 4-methylbenzenesulfonate

Base Information

• Chemical Name: Benzenemethanol, a-2-propynyl-, 4-methylbenzenesulfonate
• CAS No.: 61786-54-7
• Molecular Formula: C₁₇H₁₆O₃S
• Molecular Weight: 300.378
• Mol file: 61786-54-7.mol

Synonyms:

Chemical Property of Benzenemethanol, a-2-propynyl-, 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, a-2-propynyl-, 4-methylbenzenesulfonate

There total 1 articles about Benzenemethanol, a-2-propynyl-, 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylbut-3-yn-1-ol (1743-36-8) + p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 1-phenyl-but-3-ynyl ester (61786-54-7)

Guidance literature:

With potassium hydroxide; In diethyl ether; at -15 - 0 ℃; for 2h;

DOI:10.1016/j.jorganchem.2009.12.018

Reference yield:

tryptamine (61-54-1) + toluene-4-sulfonic acid 1-phenyl-but-3-ynyl ester (61786-54-7) → C20H20N2

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃; for 36h; Inert atmosphere;

DOI:10.1002/anie.201203303

Reference yield:

toluene-4-sulfonic acid 1-phenyl-but-3-ynyl ester (61786-54-7) → C21H20N2O (1399619-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 36 h / 85 °C / Inert atmosphere

2: 10 h / 80 °C

With potassium carbonate; In acetonitrile;

DOI:10.1002/anie.201203303

upstream raw materials:

1-phenylbut-3-yn-1-ol

p-toluenesulfonyl chloride

Downstream raw materials:

C₂₁H₂₀N₂O

Refernces