Benzaldehyde, 4-bromo-2,6-bis(3,3-dimethyl-1-butynyl)-

Base Information

Chemical Name:Benzaldehyde, 4-bromo-2,6-bis(3,3-dimethyl-1-butynyl)-
CAS No.:618119-34-9
Molecular Formula:C19H21BrO
Molecular Weight:345.279
Hs Code.:

Synonyms:

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Chemical Property of Benzaldehyde, 4-bromo-2,6-bis(3,3-dimethyl-1-butynyl)-

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Technology Process of Benzaldehyde, 4-bromo-2,6-bis(3,3-dimethyl-1-butynyl)-

There total 5 articles about Benzaldehyde, 4-bromo-2,6-bis(3,3-dimethyl-1-butynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 618119-33-8
2,6-bis(3',3'-dimethylbutynyl)-1,4-dibromobenzene

: 4-bromo-3,5-bis(3',3'-dimethylbutynyl)benzaldehyde

: 618119-34-9
4-bromo-2,6-bis(3',3'-dimethylbutynyl)benzaldehyde

Guidance literature:: 2,6-bis(3',3'-dimethylbutynyl)-1,4-dibromobenzene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo0349227

Reference yield:

: 917-92-0
3,3-Dimethylbut-1-yne

: 618119-34-9
4-bromo-2,6-bis(3',3'-dimethylbutynyl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / CuI; Et₃N / (Ph₃P)2PdCl₂ / tetrahydrofuran / 24 h / 20 °C

2.1: t-BuLi / tetrahydrofuran / 0.5 h / -78 °C

2.2: 38 percent / tetrahydrofuran / -78 - 20 °C

With copper(l) iodide; tert.-butyl lithium; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran;
DOI:10.1021/jo0349227

Reference yield:

: 3638-73-1
2,5-dibromoaniline

: 618119-34-9
4-bromo-2,6-bis(3',3'-dimethylbutynyl)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / NaOAc; ICl / acetic acid / 23 h / 80 °C

2.1: 43 percent / isoamylnitrite / dimethylformamide / 65 - 70 °C

3.1: 75 percent / CuI; Et₃N / (Ph₃P)2PdCl₂ / tetrahydrofuran / 24 h / 20 °C

4.1: t-BuLi / tetrahydrofuran / 0.5 h / -78 °C

4.2: 38 percent / tetrahydrofuran / -78 - 20 °C

With copper(l) iodide; tert.-butyl lithium; sodium acetate; Iodine monochloride; triethylamine; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo0349227