2,7-Dimethoxy-9h-carbazole

Base Information

• Chemical Name: 2,7-Dimethoxy-9h-carbazole
• CAS No.: 61822-18-2
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• Hs Code.: 2933998090
• European Community (EC) Number: 834-015-6
• DSSTox Substance ID: DTXSID70491769
• Nikkaji Number: J1.167.983H
• Wikidata: Q82336722
• Mol file: 61822-18-2.mol

Synonyms:2,7-dimethoxy-9h-carbazole;61822-18-2;2,7-dimethoxycarbazole;SCHEMBL2330779;DTXSID70491769;OFGBQGFYHXYVIA-UHFFFAOYSA-N;MFCD28154716;AKOS027385004;AS-58841;CS-0162785;D5329;T71127

Chemical Property of 2,7-Dimethoxy-9h-carbazole

Chemical Property:

• Melting Point: 285 °C
• Boiling Point: 426.7±25.0 °C(Predicted)
• PKA: 16.61±0.30(Predicted)
• PSA: 34.25000
• Density: 1.235±0.06 g/cm3(Predicted)
• LogP: 3.33830
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 227.094628657
• Heavy Atom Count: 17
• Complexity: 245

Purity/Quality:

97% ^*data from raw suppliers

2,7-Dimethoxy-9H-carbazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C3=C(N2)C=C(C=C3)OC
• Uses: 2,7-Dimethoxy-9H-carbazole is a carbazole alkaloid isolated from the root bark of clausena excavata.

Technology Process of 2,7-Dimethoxy-9h-carbazole

There total 25 articles about 2,7-Dimethoxy-9h-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methoxy-N-(3-methoxyphenyl)benzenamine (92248-06-1) → 2,7-dimethoxycarbazole (61822-18-2)

Guidance literature:

With copper diacetate; palladium diacetate; In N,N-dimethyl-formamide; at 130 ℃; for 1.16667h; Inert atmosphere; Microwave irradiation;

DOI:10.3390/molecules180910334

Reference yield: 83.0%

9-benzyl-2,7-dimethoxy-9H-carbazole (1424799-10-9) → 2,7-dimethoxycarbazole (61822-18-2)

Guidance literature:

9-benzyl-2,7-dimethoxy-9H-carbazole; With potassium tert-butylate; oxygen; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 26h; under 760.051 Torr;

With water; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1039/c2ob27432a

Reference yield: 82.0%

4,4'-dimethoxy-2-nitro-1,1'-biphenyl (13606-06-9) → 2,7-dimethoxycarbazole (61822-18-2)

Guidance literature:

With triethyl phosphite; at 160 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jo2020906

upstream raw materials:

4,4'-dimethoxy-2-nitro-1,1'-biphenyl

3-methoxy-N-(3-methoxyphenyl)benzenamine

4-bromo-3-nitroanizole

4-methoxy-2-nitroaniline

Downstream raw materials:

2,7-dimethoxy-9-(4-methoxyphenyl)carbazole

2,7-dimethoxy-9-(2-methoxyphenyl)carbazole

2,7-dimethoxy-N-(4-vinylphenyl)carbazole

2,7-dimethoxy-N-(4-formylphenyl)carbazole