3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy-

Base Information

• Chemical Name: 3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy-
• CAS No.: 61914-52-1
• Molecular Formula: C18H28O4
• Molecular Weight: 308.418
• Mol file: 61914-52-1.mol

Synonyms:1-(3,4-dimethoxyphenyl)-5-hydroxy-decan-3-one;O-Methyl-<6>-gingerol;3-Decanone,1-(3,4-dimethoxyphenyl)-5-hydroxy;<-Gingeryl-methylaether;Methylgingerol;

Chemical Property of 3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy-

Chemical Property:

• Boiling Point: 436.2±35.0 °C(Predicted)
• PSA: 55.76000
• Density: 1.037±0.06 g/cm3(Predicted)
• LogP: 3.53680

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy-

There total 6 articles about 3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

4-(3,4-dimethoxy-phenyl)-butan-2-one (6302-60-9) + hexanal (66-25-1) → 1-(3,4-dimethoxyphenyl)-5-hydroxydecan-3-one (61914-52-1)

Guidance literature:

4-(3,4-dimethoxy-phenyl)-butan-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

hexanal; In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1021/acs.jmedchem.7b01426

Reference yield: 25.0%

methylzingerone trimethylsilyl ether (61871-73-6) + hexanal (66-25-1) → 1-(3,4-dimethoxyphenyl)-5-hydroxydecan-3-one (61914-52-1)

Guidance literature:

With titanium tetrachloride; In dichloromethane; for 2.5h;

DOI:10.1039/P19810000082

Reference yield:

4-(3,4-dimethoxy-phenyl)-butan-2-one (6302-60-9) → 1-(3,4-dimethoxyphenyl)-5-hydroxydecan-3-one (61914-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium di-isopropylamide / tetrahydrofuran / 0.75 h / -78 °C

2: 25 percent / titanium tetrachloride / CH₂Cl₂ / 2.5 h

With titanium tetrachloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/P19810000082

upstream raw materials:

dimethyl sulfate

methylzingerone trimethylsilyl ether

hexanal

4-(3,4-dimethoxy-phenyl)-butan-2-one

Downstream raw materials:

hexanal

homovanillyl alcohol

2-(3,4-dimethoxyphenyl)ethyl alcohol

1-(3,4-dimethoxy-phenyl)-dec-4-en-3-one