2-Chloro-8-methoxyquinazolin-4-amine

Base Information

Chemical Name:2-Chloro-8-methoxyquinazolin-4-amine
CAS No.:61948-65-0
Molecular Formula:C₉H₈ClN₃O
Molecular Weight:209.635
Hs Code.:2933990090
DSSTox Substance ID:DTXSID20488306
Wikidata:Q82330886
Mol file:61948-65-0.mol

Synonyms:2-Chloro-8-methoxyquinazolin-4-amine;61948-65-0;4-Quinazolinamine, 2-chloro-8-methoxy-;SCHEMBL8899462;DTXSID20488306;2-Chloro-8-methoxy-4-quinazolinamine;AKOS015919790;CS-0130596;F15685;A868590

Suppliers and Price of 2-Chloro-8-methoxyquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
2-Chloro-8-methoxyquinazolin-4-amine 95%
1g
$ 529.00

American Custom Chemicals Corporation
2-CHLORO-8-METHOXYQUINAZOLIN-4-AMINE 95.00%
5MG
$ 498.37

Alichem
2-Chloro-8-methoxyquinazolin-4-amine
1g
$ 581.95

Total 16 raw suppliers

Chemical Property of 2-Chloro-8-methoxyquinazolin-4-amine

Chemical Property:

Melting Point:228℃ (methanol )
Boiling Point:353.2±24.0 °C(Predicted)
PKA:4.01±0.30(Predicted)
PSA：61.76000
Density:1.414±0.06 g/cm3(Predicted)
LogP:1.80410
Storage Temp.:2-8°C
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:209.0355896
Heavy Atom Count:14
Complexity:205

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-8-methoxyquinazolin-4-amine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC2=C1N=C(N=C2N)Cl

Technology Process of 2-Chloro-8-methoxyquinazolin-4-amine

There total 4 articles about 2-Chloro-8-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 61948-60-5
2,4-dichloro-8-methoxy-quinazoline

: 61948-65-0
2-chloro-8-methoxyquinazolin-4-amine

Guidance literature:: With ammonia; In water; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

: 62484-14-4
8-methoxyquinazoline-2,4-diol

: 61948-65-0
2-chloro-8-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 16 h / 105 °C

2: ammonium hydroxide / water; tetrahydrofuran / 20 °C

With ammonium hydroxide; trichlorophosphate; In tetrahydrofuran; water;

Reference yield:

: 3177-80-8
2-amino-3-methoxybenzoic acid

: 61948-65-0
2-chloro-8-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / water / 55 - 60 °C

2: trichlorophosphate / 16 h / 105 °C

3: ammonium hydroxide / water; tetrahydrofuran / 20 °C

With ammonium hydroxide; acetic acid; trichlorophosphate; In tetrahydrofuran; water;