Technology Process of ManuMycin B
There total 5 articles about ManuMycin B which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / tert-BuOLi / tetrahydrofuran
2: 95 percent / LiEt3BH / tetrahydrofuran / -78 °C
3: 90 percent / montmorillonite K10 / CH2Cl2 / Ambient temperature
4: 76 percent / PDC / CH2Cl2 / Ambient temperature
5: 2.) DIBAL-H / 2.) PdCl2(Ph3P)2 / 1.) THF, -78 deg C, 2.) THF, DMF, r.t.
With
dipyridinium dichromate; Montmorillonite K10; diisobutylaluminium hydride; lithium triethylborohydride; lithium tert-butoxide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 76 percent / PDC / CH2Cl2 / Ambient temperature
2: 2.) DIBAL-H / 2.) PdCl2(Ph3P)2 / 1.) THF, -78 deg C, 2.) THF, DMF, r.t.
With
dipyridinium dichromate; diisobutylaluminium hydride;
bis-triphenylphosphine-palladium(II) chloride;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / LiEt3BH / tetrahydrofuran / -78 °C
2: 90 percent / montmorillonite K10 / CH2Cl2 / Ambient temperature
3: 76 percent / PDC / CH2Cl2 / Ambient temperature
4: 2.) DIBAL-H / 2.) PdCl2(Ph3P)2 / 1.) THF, -78 deg C, 2.) THF, DMF, r.t.
With
dipyridinium dichromate; Montmorillonite K10; diisobutylaluminium hydride; lithium triethylborohydride;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane;
