R 5029

Base Information

• Chemical Name: R 5029
• CAS No.: 59708-54-2
• Molecular Formula: C₂₃H₃₀N₂O
• Molecular Weight: 350.504

Synonyms:

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Chemical Property of R 5029

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of R 5029

There total 5 articles about R 5029 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-<1-(3-Phenylpropyl)-4-piperidyl>-N-phenylpropanamide (59708-54-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH₄ / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h

2: toluene / 3 h / Heating

3: 95 percent / H₂, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr

4: sodium bicarbonate / dimethylformamide / 2.5 h / 90 - 100 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1002/jhet.5570260329

Reference yield:

N-(1-benzyl-4-piperidinyl)-N-phenylpropionamide (1474-02-8) → N-<1-(3-Phenylpropyl)-4-piperidyl>-N-phenylpropanamide (59708-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr

2: sodium bicarbonate / dimethylformamide / 2.5 h / 90 - 100 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570260329

Reference yield:

1-benzyl-N-phenylpiperidin-4-amine (1155-56-2) → N-<1-(3-Phenylpropyl)-4-piperidyl>-N-phenylpropanamide (59708-54-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 3 h / Heating

2: 95 percent / H₂, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr

3: sodium bicarbonate / dimethylformamide / 2.5 h / 90 - 100 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1002/jhet.5570260329

upstream raw materials:

1-Bromo-3-phenylpropane

Norfentanyl

1-phenylmethyl-4-piperidone

1-benzyl-N-phenylpiperidin-4-amine