Ethanone, 1-(4-bromophenyl)-2-(2-imino-3(2H)-thiazolyl)-

Base Information

• Chemical Name: Ethanone, 1-(4-bromophenyl)-2-(2-imino-3(2H)-thiazolyl)-
• CAS No.: 62284-52-0
• Molecular Formula: C₁₁H₉BrN₂OS
• Molecular Weight: 297.175
• DSSTox Substance ID: DTXSID20368053
• Wikidata: Q82154336
• ChEMBL ID: CHEMBL3302198
• Mol file: 62284-52-0.mol

Synonyms:62284-52-0;Ethanone, 1-(4-bromophenyl)-2-(2-imino-3(2H)-thiazolyl)-;Oprea1_462777;CHEMBL3302198;DTXSID20368053

Chemical Property of Ethanone, 1-(4-bromophenyl)-2-(2-imino-3(2H)-thiazolyl)-

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 295.96190
• Heavy Atom Count: 16
• Complexity: 324

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)CN2C=CSC2=N)Br

Technology Process of Ethanone, 1-(4-bromophenyl)-2-(2-imino-3(2H)-thiazolyl)-

There total 1 articles about Ethanone, 1-(4-bromophenyl)-2-(2-imino-3(2H)-thiazolyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thiazolylamine (96-50-4) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 1-(4-bromo-phenyl)-2-(2-imino-thiazol-3-yl)-ethanone (62284-52-0)

Guidance literature:

In ethanol; for 5h; Heating;

Reference yield:

1-(4-bromo-phenyl)-2-(2-imino-thiazol-3-yl)-ethanone (62284-52-0) → 2-(2-acetylimino-thiazol-3-yl)-1-(4-bromo-phenyl)-ethanol (62284-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Py / 1.5 h / Heating

2: NaBH₄ / methanol / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; In methanol;

DOI:10.1021/jm00214a021

Reference yield:

1-(4-bromo-phenyl)-2-(2-imino-thiazol-3-yl)-ethanone (62284-52-0) → 6-(4-bromo-phenyl)-5,6-dihydro-imidazo[2,1-b]thiazole (62284-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Py / 1.5 h / Heating

2: NaBH₄ / methanol / 2 h / Ambient temperature

3: (i) SOCl₂, (ii) Ac₂O

With pyridine; sodium tetrahydroborate; In methanol;

DOI:10.1021/jm00214a021

upstream raw materials:

2-thiazolylamine

para-bromophenacyl bromide

Downstream raw materials:

2-(2-acetylimino-thiazol-3-yl)-1-(4-bromo-phenyl)-ethanone

2-(2-acetylimino-thiazol-3-yl)-1-(4-bromo-phenyl)-ethanol

6-(4-bromo-phenyl)-5,6-dihydro-imidazo[2,1-b]thiazole