(5-Bromo-2-methoxyphenyl)(furan-2-yl)methanone

Base Information

Chemical Name:(5-Bromo-2-methoxyphenyl)(furan-2-yl)methanone
CAS No.:62457-33-4
Molecular Formula:C12H9BrO3
Molecular Weight:281.106
Hs Code.:
DSSTox Substance ID:DTXSID10656072
Wikidata:Q82570537

Synonyms:62457-33-4;(5-Bromo-2-methoxyphenyl)(furan-2-yl)methanone;DTXSID10656072

Suppliers and Price of (5-Bromo-2-methoxyphenyl)(furan-2-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of (5-Bromo-2-methoxyphenyl)(furan-2-yl)methanone

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:279.97351
Heavy Atom Count:16
Complexity:257

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)Br)C(=O)C2=CC=CO2

Technology Process of (5-Bromo-2-methoxyphenyl)(furan-2-yl)methanone

There total 2 articles about (5-Bromo-2-methoxyphenyl)(furan-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 527-69-5
2-furancarbonyl chloride

: 104-92-7
1-bromo-4-methoxy-benzene

: 62457-33-4
(5-bromo-2-methoxyphenyl)(furan-2-yl)methanone

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 50 - 60 ℃; for 12h;
DOI:10.3390/molecules16064897

Reference yield:

: 88-14-2
2-furanoic acid

: 62457-33-4
(5-bromo-2-methoxyphenyl)(furan-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 5 h / 80 - 90 °C

2: aluminum (III) chloride / dichloromethane / 12 h / 50 - 60 °C

With aluminum (III) chloride; thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; 2: Friedel Crafts acylation;
DOI:10.3390/molecules16064897

Reference yield: 94.0%

: 62457-33-4
(5-bromo-2-methoxyphenyl)(furan-2-yl)methanone

: 53877-99-9
(5-bromo-2-hydroxyphenyl)(furan-2-yl)methanone

Guidance literature:: (5-bromo-2-methoxyphenyl)(furan-2-yl)methanone; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 4h;

With water; In dichloromethane; Cooling with ice;
DOI:10.3390/molecules16064897