2,4-Hexadienedioic acid, 2-methoxy-5-(phenylmethoxy)-, dimethyl ester, (E,Z)-

Base Information

• Chemical Name: 2,4-Hexadienedioic acid, 2-methoxy-5-(phenylmethoxy)-, dimethyl ester, (E,Z)-
• CAS No.: 62478-21-1
• Molecular Formula: C₁₆H₁₈O₆
• Molecular Weight: 306.315
• Mol file: 62478-21-1.mol

Synonyms:

Chemical Property of 2,4-Hexadienedioic acid, 2-methoxy-5-(phenylmethoxy)-, dimethyl ester, (E,Z)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Hexadienedioic acid, 2-methoxy-5-(phenylmethoxy)-, dimethyl ester, (E,Z)-

There total 5 articles about 2,4-Hexadienedioic acid, 2-methoxy-5-(phenylmethoxy)-, dimethyl ester, (E,Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E,4Z)-2-Benzoxy-5-methoxy-6-oxo-2,4-hexadiensaeure (62478-18-6) → Dimethyl-(2E,4Z)-2-benzyloxy-5-methoxy-2,4-hexadiendioat (62478-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Ag₂O, aq. NaOH / tetrahydrofuran

With sodium hydroxide; silver(l) oxide; In tetrahydrofuran;

Reference yield:

(S)-3-Benzyloxy-5-((S)-2-hydroxy-1-methoxy-ethyl)-5H-furan-2-one → Dimethyl-(2E,4Z)-2-benzyloxy-5-methoxy-2,4-hexadiendioat (62478-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N, Py, SO₃ / dimethylsulfoxide

2: Ag₂O, aq. NaOH / tetrahydrofuran

With pyridine; sodium hydroxide; sulfur trioxide; triethylamine; silver(l) oxide; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

(3S,3aS,5R,6R,6aS)-3-Benzyloxy-5,6-dimethoxy-tetrahydro-furo[3,2-b]furan-2-one → Dimethyl-(2E,4Z)-2-benzyloxy-5-methoxy-2,4-hexadiendioat (62478-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1: DBU / CHCl₃

2: Ag₂O, aq. NaOH / tetrahydrofuran

With sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; silver(l) oxide; In tetrahydrofuran; chloroform;

upstream raw materials:

diazomethane

2-O-Benzyl-3-desoxy-5-O-methyl-L-threo-hex-2-enaro-1,4-lacton-methylester

(2E,4Z)-2-Benzoxy-5-methoxy-6-oxo-2,4-hexadiensaeure