(4S)-4-{[2-(Benzyloxy)phenoxy]methyl}-2,2-dimethyl-1,3-dioxolane

Base Information

• Chemical Name: (4S)-4-{[2-(Benzyloxy)phenoxy]methyl}-2,2-dimethyl-1,3-dioxolane
• CAS No.: 62501-66-0
• Molecular Formula: C19H22O4
• Molecular Weight: 314.381
• DSSTox Substance ID: DTXSID70494851
• Wikidata: Q82342536
• Mol file: 62501-66-0.mol

Synonyms:62501-66-0;DTXSID70494851;(4S)-4-{[2-(Benzyloxy)phenoxy]methyl}-2,2-dimethyl-1,3-dioxolane

Chemical Property of (4S)-4-{[2-(Benzyloxy)phenoxy]methyl}-2,2-dimethyl-1,3-dioxolane

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 314.15180918
• Heavy Atom Count: 23
• Complexity: 351

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OCC(O1)COC2=CC=CC=C2OCC3=CC=CC=C3)C
• Isomeric SMILES: CC1(OC[C@@H](O1)COC2=CC=CC=C2OCC3=CC=CC=C3)C

Technology Process of (4S)-4-{[2-(Benzyloxy)phenoxy]methyl}-2,2-dimethyl-1,3-dioxolane

There total 3 articles about (4S)-4-{[2-(Benzyloxy)phenoxy]methyl}-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol (22323-82-6,36543-79-0) → (2S)-3-(2'-benzyloxyphenoxy)-1,2-propanediol acetonide (62501-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0 °C

2: NaH / ethanol / Heating

With pyridine; sodium hydride; In ethanol;

Reference yield:

O-benzylcatechol (6272-38-4) + (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate (23788-74-1,7305-59-1) → (2S)-3-(2'-benzyloxyphenoxy)-1,2-propanediol acetonide (62501-66-0)

Guidance literature:

With sodium hydride; In ethanol; Heating;

Reference yield:

→ (2S)-3-(2'-benzyloxyphenoxy)-1,2-propanediol acetonide (62501-66-0)

Guidance literature:

Aus 2-Benzyloxyphenol, NaOCH3 u. (2R)-3-Tosyloxy-1,2-propandiolacetonid 6;

DOI:10.1021/jm00217a002

upstream raw materials:

O-benzylcatechol

(R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate

(S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol

Downstream raw materials:

(2R)-3-(2'-benzyloxyphenoxy)-1,2-propanediol

(2S)-3-(2'-benzyloxyphenoxy)-1,2-propanediol ditosylate

(2S)-3-(2'-hydroxyphenoxy)-1,2-propanediol ditosylate