Chemical Property of Nelociguat
Chemical Property:
- Melting Point:>196oC (dec.)
- Boiling Point:533.3±50.0 °C(Predicted)
- PKA:10.68±0.70(Predicted)
- PSA：151.08000
- Density:1.58±0.1 g/cm3(Predicted)
- LogP:2.94330
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
- XLogP3:1.4
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:5
- Exact Mass:408.14584998
- Heavy Atom Count:30
- Complexity:589
- Purity/Quality:
-
97% *data from raw suppliers
N-DesmethylRiociguat *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N
- Recent ClinicalTrials:Single Dose Escalation Study in Patients With Chronic Heart Failure
- Recent EU Clinical Trials:A prospective, randomized, double-blind, double-dummy, placebo- and active controlled, multicenter study assessing the efficacy and safety of the combination BAY 60 4552 / vardenafil compared to vardenafil (20 mg) for the treatment of erectile dysfunction not sufficiently responsive to standard therapy with PDE5 inhibitors
-
Uses
N-Desmethyl-riociguat, is a complex that is part affiliated with potent oral stimulator for the treatment of pulmonary hypertension.
