6-Benzoxazolesulfonamide, 2,3-dihydro-3-methyl-2-oxo-

Base Information

• Chemical Name: 6-Benzoxazolesulfonamide, 2,3-dihydro-3-methyl-2-oxo-
• CAS No.: 62522-62-7
• Molecular Formula: C8H8N2O4S
• Molecular Weight: 228.229
• Mol file: 62522-62-7.mol

Synonyms:3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide;3-methyl-2-oxo-2,3-dihydro-benzooxazole-6-sulfonic acid amide;3-Methyl-6-sulfonamido-benzoxazolon;

Chemical Property of 6-Benzoxazolesulfonamide, 2,3-dihydro-3-methyl-2-oxo-

Chemical Property:

• PSA: 103.68000
• LogP: 1.56000

Purity/Quality:

99% ^*data from raw suppliers

3-Methyl-2-oxo-2,3-dihydrobenzooxazole-6-sulfonic acid amide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Benzoxazolesulfonamide, 2,3-dihydro-3-methyl-2-oxo-

There total 4 articles about 6-Benzoxazolesulfonamide, 2,3-dihydro-3-methyl-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride (62522-63-8) → 3-methylbenzoxazolone-6-sulfonamide (62522-62-7)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 1.5h; Inert atmosphere; Cooling with ice;

Reference yield:

3-methylbenzo[d]oxazol-2(3H)-one (21892-80-8) → 3-methylbenzoxazolone-6-sulfonamide (62522-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ClSO₃H / 3 h

2: NH₃ / ethanol / 2 h / Heating

With chlorosulfonic acid; ammonia; In ethanol;

DOI:10.1007/BF00758030

Reference yield:

2-Benzoxazolinone (59-49-4) → 3-methylbenzoxazolone-6-sulfonamide (62522-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2: chlorosulfonic acid / dichloromethane / 10 h / Inert atmosphere; Cooling with ice

3: ammonia / methanol / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice

With chlorosulfonic acid; ammonia; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

2-oxo-2,3-dihydro-benzooxazole-6-sulfonic acid amide

dimethyl sulfate

3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride

3-methylbenzo[d]oxazol-2(3H)-one