5-Heptenoic acid, 7-[2-[4-(4-chlorophenoxy)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butenyl]-3, 5-bis[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]-2-(phenylseleno)-, methyl ester

Base Information

Chemical Name:5-Heptenoic acid, 7-[2-[4-(4-chlorophenoxy)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butenyl]-3, 5-bis[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]-2-(phenylseleno)-, methyl ester
CAS No.:62525-20-6
Molecular Formula:C44H59ClO9Se
Molecular Weight:846.36
Hs Code.:

5-Heptenoic acid,
7-[2-[4-(4-chlorophenoxy)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butenyl]-3,
5-bis[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]-2-(phenylseleno)-,
methyl ester

Synonyms:

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Chemical Property of 5-Heptenoic acid, 7-[2-[4-(4-chlorophenoxy)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butenyl]-3, 5-bis[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]-2-(phenylseleno)-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Heptenoic acid, 7-[2-[4-(4-chlorophenoxy)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butenyl]-3, 5-bis[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]-2-(phenylseleno)-, methyl ester

There total 10 articles about 5-Heptenoic acid, 7-[2-[4-(4-chlorophenoxy)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butenyl]-3, 5-bis[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]-2-(phenylseleno)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40665-86-9
dimethyl 3-(4-chlorophenoxy)-2-oxopropylphosphonate

: 62525-20-6
(Z)-7-[(1R,2R,3R,5S)-2-[(E)-(R)-4-(4-Chloro-phenoxy)-3-(tetrahydro-pyran-2-yloxy)-but-1-enyl]-3,5-bis-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-2-phenylselanyl-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, 25 deg C, 20 min, 2.) THF, from 25 deg C to 60 deg C, 4.5 h

2: NaBH₄ / methanol; tetrahydrofuran / -45 °C

3: K₂CO₃ / methanol / 1 h / 50 °C

4: p-toluenesulfonic acid / CH₂Cl₂ / 0.33 h / 25 °C

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) 20 deg C, 30 min

With sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00179a011

Reference yield:

: 61218-06-2
methyl (Z)-7-[(1R,2R,3R,5S)-5-acetoxy-2-formyl-3-(2-tetrahydropyranyloxy)cyclopentyl]-5-heptenate

: 62525-20-6
(Z)-7-[(1R,2R,3R,5S)-2-[(E)-(R)-4-(4-Chloro-phenoxy)-3-(tetrahydro-pyran-2-yloxy)-but-1-enyl]-3,5-bis-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-2-phenylselanyl-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, 25 deg C, 20 min, 2.) THF, from 25 deg C to 60 deg C, 4.5 h

2: NaBH₄ / methanol; tetrahydrofuran / -45 °C

3: K₂CO₃ / methanol / 1 h / 50 °C

4: p-toluenesulfonic acid / CH₂Cl₂ / 0.33 h / 25 °C

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) 20 deg C, 30 min

With sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00179a011

Reference yield:

: 61218-10-8
methyl (5Z)-7-{(1R,2S,3R,5R)-5-acetoxy-2-hydroxymethyl-3-[(2-oxacyclohexyl)oxy]-cyclopentyl}-5-heptenoate

: 62525-20-6
(Z)-7-[(1R,2R,3R,5S)-2-[(E)-(R)-4-(4-Chloro-phenoxy)-3-(tetrahydro-pyran-2-yloxy)-but-1-enyl]-3,5-bis-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-2-phenylselanyl-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / SO₃-pyridine complex, Et₃N / dimethylsulfoxide / 0.25 h / 20 °C

2: 1.) NaH / 1.) THF, 25 deg C, 20 min, 2.) THF, from 25 deg C to 60 deg C, 4.5 h

3: NaBH₄ / methanol; tetrahydrofuran / -45 °C

4: K₂CO₃ / methanol / 1 h / 50 °C

5: p-toluenesulfonic acid / CH₂Cl₂ / 0.33 h / 25 °C

6: 1.) LDA / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) 20 deg C, 30 min

With sodium tetrahydroborate; pyridine-SO₃ complex; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00179a011