3-Chloro-3-(4-fluorophenyl)methacrylaldehyde

Base Information

Chemical Name:3-Chloro-3-(4-fluorophenyl)methacrylaldehyde
CAS No.:83783-51-1
Molecular Formula:C₁₀H₈ClFO
Molecular Weight:198.624
Hs Code.:
European Community (EC) Number:280-785-6
Nikkaji Number:J296.208J
Mol file:83783-51-1.mol

Synonyms:83783-51-1;3-Chloro-3-(4-fluorophenyl)methacrylaldehyde;EINECS 280-785-6;(2Z)-3-Chloro-3-(4-fluorophenyl)-2-methylacrylaldehyde;C10H8ClFO;C10-H8-Cl-F-O;AKOS020184148;3-Chloro-3-(4-fluorophenyl)-2-methylpropenal

Suppliers and Price of 3-Chloro-3-(4-fluorophenyl)methacrylaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 3-Chloro-3-(4-fluorophenyl)methacrylaldehyde

Chemical Property:

Vapor Pressure:0.00817mmHg at 25°C
Boiling Point:267.4°C at 760 mmHg
Flash Point:115.5°C
PSA：17.07000
Density:1.218g/cm³
LogP:2.99440
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:198.0247707
Heavy Atom Count:13
Complexity:217

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=C(C1=CC=C(C=C1)F)Cl)C=O
Isomeric SMILES:C/C(=C(\C1=CC=C(C=C1)F)/Cl)/C=O

Technology Process of 3-Chloro-3-(4-fluorophenyl)methacrylaldehyde

There total 2 articles about 3-Chloro-3-(4-fluorophenyl)methacrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 456-03-1
1-(4-fluorophenyl)propan-1-one

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 83783-51-1
(E)-3-chloro-3-(4-fluorophenyl)-2-methylacrylaldehyde

: 83783-51-1
(Z)-3-chloro-3-(4-fluorophenyl)-2-methylacrylaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 20 ℃; for 0.583333h; Inert atmosphere;

1-(4-fluorophenyl)propan-1-one; at 0 - 40 ℃; for 7h; Overall yield = 80 %; Overall yield = 521 mg; Inert atmosphere;
DOI:10.1021/acs.orglett.5b01312

Reference yield:

: 456-03-1
1-(4-fluorophenyl)propan-1-one

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 83783-51-1
(E)-3-chloro-3-(4-fluorophenyl)-2-methylacrylaldehyde

: 83783-51-1
(Z)-3-chloro-3-(4-fluorophenyl)-2-methylacrylaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 20 ℃; for 0.583333h; Inert atmosphere;

1-(4-fluorophenyl)propan-1-one; at 0 - 40 ℃; for 7h; Overall yield = 80 %; Overall yield = 521 mg; Inert atmosphere;
DOI:10.1021/acs.orglett.5b01312