4,5-Dibromo-1-(2-phenylethyl)-1H-pyrrole-2-carbonyl chloride

Base Information

Chemical Name:4,5-Dibromo-1-(2-phenylethyl)-1H-pyrrole-2-carbonyl chloride
CAS No.:62541-36-0
Molecular Formula:C13H10Br2ClNO
Molecular Weight:391.489
Hs Code.:
DSSTox Substance ID:DTXSID00522439
Wikidata:Q82387699

Synonyms:62541-36-0;DTXSID00522439;4,5-Dibromo-1-(2-phenylethyl)-1H-pyrrole-2-carbonyl chloride

Suppliers and Price of 4,5-Dibromo-1-(2-phenylethyl)-1H-pyrrole-2-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-Dibromo-1-(2-phenylethyl)-1H-pyrrole-2-carbonyl chloride

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:390.87972
Heavy Atom Count:18
Complexity:297

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCN2C(=CC(=C2Br)Br)C(=O)Cl

Technology Process of 4,5-Dibromo-1-(2-phenylethyl)-1H-pyrrole-2-carbonyl chloride

There total 6 articles about 4,5-Dibromo-1-(2-phenylethyl)-1H-pyrrole-2-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 62541-35-9
4,5-Dibromo-1-(2-phenethyl)pyrrole-2-carboxylic Acid

: 62541-36-0
4,5-Dibromo-1-phenethyl-1H-pyrrole-2-carbonyl chloride

Guidance literature:: With thionyl chloride; for 0.5h; Heating;
DOI:10.1021/jo00167a015

Reference yield:

: 34600-57-2
N-(trans-Styryl)pyrrol-2-carbonsaeure

: 62541-36-0
4,5-Dibromo-1-phenethyl-1H-pyrrole-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂ / 10percent Pd/C / ethanol / 2280 Torr

2: 77 percent / Br₂ / acetic acid / 0.25 h / Ambient temperature

3: 97 percent / SOCl₂ / 0.5 h / Heating

With thionyl chloride; hydrogen; bromine; palladium on activated charcoal; In ethanol; acetic acid;
DOI:10.1021/jo00167a015

Reference yield:

: 1193-62-0
methyl Pyrrole-2-carboxylate

: 62541-36-0
4,5-Dibromo-1-phenethyl-1H-pyrrole-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / K₂CO₃ / dimethylformamide / 4 h / 85 °C

2: 95 percent / 6 N NaOH / ethanol / 2 h / Heating

3: 77 percent / Br₂ / acetic acid / 0.25 h / Ambient temperature

4: 97 percent / SOCl₂ / 0.5 h / Heating

With sodium hydroxide; thionyl chloride; bromine; potassium carbonate; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00167a015