3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione

Base Information

Chemical Name:3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
CAS No.:131848-97-0
Molecular Formula:C₂₆H₂₄N₄O₂
Molecular Weight:424.502
Hs Code.:2925199590
DSSTox Substance ID:DTXSID60927365
Nikkaji Number:J468.918F
ChEMBL ID:CHEMBL421565
Mol file:131848-97-0.mol

Synonyms:Ro 31-8425;Ro-31-8425;Ro31.8425

Suppliers and Price of 3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Ro-31-8425
1mg
$ 140.60

Iris Biotech GmbH
BisindolylmaleimideX
1 mg
$ 270.00

American Custom Chemicals Corporation
BISINDOLYLMALEIMIDE X 95.00%
5MG
$ 516.00

Total 8 raw suppliers

Chemical Property of 3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione

Chemical Property:

Vapor Pressure:1.56E-21mmHg at 25°C
Refractive Index:1.755
Boiling Point:736.1 °C at 760 mmHg
Flash Point:399 °C
PSA：82.05000
Density:1.43 g/cm³
LogP:4.25040
Storage Temp.:0-6°C
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:424.18992602
Heavy Atom Count:32
Complexity:825

Purity/Quality:

99% ^*data from raw suppliers

Ro-31-8425 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN

Technology Process of 3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione

There total 5 articles about 3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Trifluoro-methanesulfonic acid 10-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-8-ylmethyl ester

: 151342-35-7,131848-97-0
3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione

Guidance literature:: With ammonium hydroxide; In dichloromethane; for 17h; Yield given;
DOI:10.1021/jm00053a003

Reference yield:

: 131849-03-1
8-(acetoxymethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indole

: 151342-35-7,131848-97-0
3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 0.5 h

2: Et₃N / CH₂Cl₂ / 65 h

3: 94 percent / 33percent aq. NH₃ / dimethylformamide / 9 h / 140 °C

4: 2,4,6-collidine / CH₂Cl₂ / 2 h

5: 33percent aq. NH₃ / CH₂Cl₂ / 17 h

With 2,4,6-trimethyl-pyridine; ammonium hydroxide; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00053a003

Reference yield:

: 131849-81-5
Acetic acid 10-chlorooxalyl-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-8-ylmethyl ester

: 151342-35-7,131848-97-0
3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 65 h

2: 94 percent / 33percent aq. NH₃ / dimethylformamide / 9 h / 140 °C

3: 2,4,6-collidine / CH₂Cl₂ / 2 h

4: 33percent aq. NH₃ / CH₂Cl₂ / 17 h

With 2,4,6-trimethyl-pyridine; ammonium hydroxide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00053a003