2-(1,3-Dihydro-2-benzofuran-1-yl)acetic acid

Base Information

Chemical Name:2-(1,3-Dihydro-2-benzofuran-1-yl)acetic acid
CAS No.:62590-78-7
Molecular Formula:C10H10O3
Molecular Weight:178.18500
Hs Code.:
European Community (EC) Number:899-562-5
DSSTox Substance ID:DTXSID10608096

Synonyms:2-(1,3-dihydro-2-benzofuran-1-yl)acetic acid;170856-90-3;(1,3-Dihydro-2-benzofuran-1-yl)acetic acid;SCHEMBL7405122;DTXSID10608096;DB-092838;2-(1,3-dihydro-2-benzofuran-1-yl)aceticacid;EN300-269208

Suppliers and Price of 2-(1,3-Dihydro-2-benzofuran-1-yl)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2,3-DIHYDRO-BENZOFURAN-2-YL)ACETIC ACID 95.00%
5MG
$ 498.96

Total 4 raw suppliers

Chemical Property of 2-(1,3-Dihydro-2-benzofuran-1-yl)acetic acid

Chemical Property:

PSA：46.53000
LogP:1.73260
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:178.062994177
Heavy Atom Count:13
Complexity:202

Purity/Quality:

97% ^*data from raw suppliers

(2,3-DIHYDRO-BENZOFURAN-2-YL)ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=CC=CC=C2C(O1)CC(=O)O

Technology Process of 2-(1,3-Dihydro-2-benzofuran-1-yl)acetic acid

There total 4 articles about 2-(1,3-Dihydro-2-benzofuran-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (E)-4-(2-hydroxyphenyl)buta-2-enoic-acid

: 62590-78-7
2-(2,3-dihydrobenzofuran-2-yl)acetic acid

Guidance literature:: With 2-[(N,N-diisopropylamino)methyl]phenylboronic acid; In acetonitrile; at 50 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol501954r

Reference yield:

: 1745-81-9
o-Allylphenol

: 62590-78-7
2-(2,3-dihydrobenzofuran-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / diethyl ether / 19 h / 20 - 40 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

3: 2-[(N,N-diisopropylamino)methyl]phenylboronic acid / acetonitrile / 12 h / 50 °C / Inert atmosphere

With 2-[(N,N-diisopropylamino)methyl]phenylboronic acid; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; copper(l) iodide; trifluoroacetic acid; In diethyl ether; dichloromethane; acetonitrile; 3: |Michael Addition;
DOI:10.1021/ol501954r

Reference yield:

: 1427349-32-3
(E)-4-(2-hydroxy-phenyl)-but-2-enoic acid tert-butyl ester

: 62590-78-7
2-(2,3-dihydrobenzofuran-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2: 2-[(N,N-diisopropylamino)methyl]phenylboronic acid / acetonitrile / 12 h / 50 °C / Inert atmosphere

With 2-[(N,N-diisopropylamino)methyl]phenylboronic acid; trifluoroacetic acid; In dichloromethane; acetonitrile; 2: |Michael Addition;
DOI:10.1021/ol501954r