N-ethyl-N-methylformamide

Base Information

• Chemical Name: N-ethyl-N-methylformamide
• CAS No.: 28860-25-5
• Molecular Formula: C4H9 N O
• Molecular Weight: 87.1216
• Hs Code.: 2924199090
• European Community (EC) Number: 800-174-5
• NSC Number: 514424
• DSSTox Substance ID: DTXSID90325638
• Nikkaji Number: J655.956E
• Wikidata: Q82086129
• Mol file: 28860-25-5.mol

Synonyms:N-ethyl-N-methylformamide;28860-25-5;Formamide, N-ethyl-N-methyl-;N-ETHYL-N-METHYL-FORMAMIDE;ethylmethylformamide;NSC514424;DTXSID90325638;AKOS009460922;NSC 514424;NSC-514424;EN300-106885;Z1258520870

Chemical Property of N-ethyl-N-methylformamide

Chemical Property:

• Vapor Pressure: 2.04mmHg at 25°C
• Boiling Point: 163.7°Cat760mmHg
• Flash Point: 61.8°C
• PSA: 20.31000
• Density: 0.878g/cm³
• LogP: 0.73040
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 87.068413911
• Heavy Atom Count: 6
• Complexity: 44.8

Purity/Quality:

98% ^*data from raw suppliers

N-ETHYL-N-METHYLFORMAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(C)C=O

Technology Process of N-ethyl-N-methylformamide

There total 2 articles about N-ethyl-N-methylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Methyl-O-p-nitrophenylsulphonylhydroxylamine (85462-16-4) + propionaldehyde (123-38-6) → N-methylpropanamide (1187-58-2) + N-methyl-N-ethylformamide (28860-25-5)

Guidance literature:

In chloroform-d1; for 6h; Ambient temperature;

DOI:10.1021/jo00042a032

Reference yield:

methyl radical (2229-07-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethyl acetamide (127-19-5,116057-81-9) + N-methyl-N-ethylformamide (28860-25-5)

Guidance literature:

Thermodynamic data; Mechanism; calculated (BEBO and equibonding method) activation energies for hydrogen atom transfer reaction, anodic methylation;

Reference yield: 66.0%

N-methyl-N-ethylformamide (28860-25-5) + 6-(4-methylpentyloxy)-2,5-diphenylpyridin-3-ylamine (1049706-53-7) → N-ethyl-N-methyl-N'-[6-(4-methylpentyloxy)-2,5-diphenylpyridin-3-yl]formamidine

Guidance literature:

N-methyl-N-ethylformamide; With trichlorophosphate; In dichloromethane; at 20 ℃; for 1.5h;

6-(4-methylpentyloxy)-2,5-diphenylpyridin-3-ylamine; In dichloromethane; at 20 ℃; for 3.5h;

With sodium hydroxide; In dichloromethane; water; at 0 ℃; for 0.166667h; pH=~ 12;

upstream raw materials:

N-Methyl-O-p-nitrophenylsulphonylhydroxylamine

propionaldehyde

methyl radical

N,N-dimethyl-formamide

Downstream raw materials:

N'-(2-benzyl-3,6-dimethyl-benzofuran-5-yl)-N-ethyl-N-methyl-formamidine

N'-(2-benzyl-3,4-dimethyl-benzofuran-5-yl)-N-ethyl-N-methyl-formamidine

N-ethyl-N-methyl-N'-(4-methyl-2-phenethyl-benzofuran-5-yl)-formamidine

N-ethyl-N-methyl-N'-(6-methyl-2-phenethyl-benzofuran-5-yl)-formamidine

Refernces

• 1、 Eberson, Lennart. "Direct vs. Indirect Mechanisms in Organic Electrochemistry. Estimates of Activation Energies for Hydrogen Atom Transfer Processes of Relevance in Indirect Mechanisms Using the Bond Energy-Bond Order (BEBO) and Equibonding Methods". . p. 481 - 492. Retrieved 2007/10/02.