1-Piperazinecarboxylic acid, 4-(2-formylphenyl)-, phenylmethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-(2-formylphenyl)-, phenylmethyl ester
CAS No.:626218-86-8
Molecular Formula:C19H20N2O3
Molecular Weight:324.379
Hs Code.:
DSSTox Substance ID:DTXSID80459618
Wikidata:Q82283435

Synonyms:1-Piperazinecarboxylic acid, 4-(2-formylphenyl)-, phenylmethyl ester;626218-86-8;DTXSID80459618

Suppliers and Price of 1-Piperazinecarboxylic acid, 4-(2-formylphenyl)-, phenylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperazinecarboxylic acid, 4-(2-formylphenyl)-, phenylmethyl ester

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:324.14739250
Heavy Atom Count:24
Complexity:415

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1C2=CC=CC=C2C=O)C(=O)OCC3=CC=CC=C3

Technology Process of 1-Piperazinecarboxylic acid, 4-(2-formylphenyl)-, phenylmethyl ester

There total 1 articles about 1-Piperazinecarboxylic acid, 4-(2-formylphenyl)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 446-52-6
2-Fluorobenzaldehyde

: 626218-86-8
2-(4-Cbz-piperazine)benzaldehyde

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 19h;
DOI:10.1021/jm049278i

Reference yield:

: 626218-86-8
2-(4-Cbz-piperazine)benzaldehyde

: 626218-95-9
N-Boc-N-[2-(2-thienyl)ethyl]-2-piperazinebenzylamine

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH(OAc)3 / CH₂Cl₂ / 16 h / 20 °C

2: CH₂Cl₂ / 6 h / 20 °C

3: 35 percent / H₂; NH₃ / Pd/C / methanol / 23 h / 20 °C / 2068.59 Torr

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.03.053

Reference yield:

: 626218-86-8
2-(4-Cbz-piperazine)benzaldehyde

: 834917-26-9
4-[(2R)-amino-3-(2,4-dichlorophenyl)propionyl]-1-{2-[N-Boc-(2-thienyl)ethylaminomethyl]phenyl}piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH(OAc)3 / CH₂Cl₂ / 16 h / 20 °C

2: CH₂Cl₂ / 6 h / 20 °C

3: 35 percent / H₂; NH₃ / Pd/C / methanol / 23 h / 20 °C / 2068.59 Torr

4: EDC; HOBt / CH₂Cl₂ / 18 h / 20 °C

5: Et₂NH / CH₂Cl₂ / 3 h / 20 °C

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.03.053