6-(Benzenesulfinyl)tetrazolo[1,5-b]pyridazine

Base Information

• Chemical Name: 6-(Benzenesulfinyl)tetrazolo[1,5-b]pyridazine
• CAS No.: 62645-28-7
• Molecular Formula: C10H7N5OS
• Molecular Weight: 245.26000
• DSSTox Substance ID: DTXSID80397884
• Nikkaji Number: J1.773.762G
• Wikidata: Q27189566
• ChEMBL ID: CHEMBL271023
• Mol file: 62645-28-7.mol

Synonyms:Ro 106-9920;Ro-106-9920;Ro106-9920

Chemical Property of 6-(Benzenesulfinyl)tetrazolo[1,5-b]pyridazine

Chemical Property:

• PSA: 92.25000
• Density: 1.67g/cm3
• LogP: 1.55170
• Storage Temp.: Store at +4°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 245.03713104
• Heavy Atom Count: 17
• Complexity: 296

Purity/Quality:

98%min ^*data from raw suppliers

Ro 106-9920 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)S(=O)C2=NN3C(=NN=N3)C=C2
• Uses: Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Technology Process of 6-(Benzenesulfinyl)tetrazolo[1,5-b]pyridazine

There total 1 articles about 6-(Benzenesulfinyl)tetrazolo[1,5-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Ro 106-9920 (62645-28-7)

Guidance literature:

6-Phenyltetrazolo-<1.5-b>pyridazin, Metachlorbenzoesaeure;

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