1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-1-(2-fluoroethyl)-4-oxo-7-(1-piperazinyl)-

Base Information

• Chemical Name: 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-1-(2-fluoroethyl)-4-oxo-7-(1-piperazinyl)-
• CAS No.: 84209-34-7
• Molecular Formula: C₁₅H₁₆F₂N₄O₃
• Molecular Weight: 338.314
• DSSTox Substance ID: DTXSID60233130
• Wikidata: Q83114486
• ChEMBL ID: CHEMBL291131
• Mol file: 84209-34-7.mol

Synonyms:84209-34-7;BRN 6073801;1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-1-(2-fluoroethyl)-4-oxo-7-(1-piperazinyl)-;1,4-Dihydro-6-Fluoro-1-(2-Fluoroethyl)-4-Oxo-7-(1-Piperazinyl)-1,8-Naphthyridine-3-Carboxylic Acid;CHEMBL291131;SCHEMBL11006503;DTXSID60233130;C15H16F2N4O3;UDVOCWCSFKHVEL-UHFFFAOYSA-N;LS-95952;6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid

Chemical Property of 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-1-(2-fluoroethyl)-4-oxo-7-(1-piperazinyl)-

Chemical Property:

• Vapor Pressure: 1.08E-14mmHg at 25°C
• Boiling Point: 588.4°C at 760 mmHg
• Flash Point: 309.7°C
• PSA: 87.46000
• Density: 1.432g/cm³
• LogP: 1.00670
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 338.11904671
• Heavy Atom Count: 24
• Complexity: 539

Purity/Quality:

1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 1,4-DIHYDRO-6-FLUORO-1-(2-FLUOROE THYL)-4-OXO-7-(1-PIPERAZINYL)- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=C(C=C3C(=O)C(=CN(C3=N2)CCF)C(=O)O)F

Technology Process of 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-1-(2-fluoroethyl)-4-oxo-7-(1-piperazinyl)-

There total 1 articles about 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-1-(2-fluoroethyl)-4-oxo-7-(1-piperazinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid (84209-34-7)

Guidance literature:

Reference yield: 82.2%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid (84209-34-7) → 6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid (84209-33-6)

Guidance literature:

With formic acid; In water; at 120 - 125 ℃; for 17h;

DOI:10.1021/jm00369a011

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + active charcoal + 6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid (84209-34-7) → 6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid (84209-33-6)

Guidance literature:

With formic acid; In ammonium hydroxide;

Downstream raw materials:

6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid

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