(2,5-Dibromophenyl)hydrazine

Base Information

• Chemical Name: (2,5-Dibromophenyl)hydrazine
• CAS No.: 62672-26-8
• Molecular Formula: C6H6Br2N2
• Molecular Weight: 265.93300
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID70397111
• Nikkaji Number: J90.208J
• Wikidata: Q72464821
• Mol file: 62672-26-8.mol

Synonyms:(2,5-dibromophenyl)hydrazine;62672-26-8;Hydrazine, (2,5-dibromophenyl)-;SCHEMBL9983346;YSZC2033;(2,5-Dibromo-phenyl)-hydrazine;DTXSID70397111;MFCD02663135;AKOS010727879;DS-5439;QC-934;2,5-dibromophenylhydrazine;SB74687;AM808062;BB 0249795;CS-0157147;A868403

Chemical Property of (2,5-Dibromophenyl)hydrazine

Chemical Property:

• Boiling Point: 306.9±32.0 °C(Predicted)
• PKA: 4.31±0.10(Predicted)
• PSA: 38.05000
• Density: 2.070±0.06 g/cm3(Predicted)
• LogP: 3.27050
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 265.88772
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2,5-Dibromophenyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Br)NN)Br

Technology Process of (2,5-Dibromophenyl)hydrazine

There total 3 articles about (2,5-Dibromophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2,5-dibromoaniline (3638-73-1) → (2,5-dibromophenyl)hydrazine (62672-26-8)

Guidance literature:

2,5-dibromoaniline; With hydrogenchloride; sodium nitrite; at 0 ℃; for 1h;

With hydrogenchloride; urea; tin(ll) chloride; cooling;

DOI:10.1021/jo062124l

Reference yield:

1,4-dibromo-2-nitrobenzene (3460-18-2) → (2,5-dibromophenyl)hydrazine (62672-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(ll) chloride; hydrogenchloride / ethanol; water / 12 h / Reflux

2.1: sodium nitrite / water / 1 h / 0 °C

2.2: 0.17 h / 0 °C

2.3: 4 h / 0 °C

With hydrogenchloride; tin(ll) chloride; sodium nitrite; In ethanol; water;

DOI:10.1002/anie.202016826

Reference yield:

→ (2,5-dibromophenyl)hydrazine (62672-26-8)

Guidance literature:

aus /BRN= 817548/ durch Diazotierung u. Red. m. SnCl2;

upstream raw materials:

2,5-dibromoaniline

1,4-dibromo-2-nitrobenzene

Downstream raw materials:

9-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-2-trityl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-6-carboxamide

9-bromo-2-trityl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-6-carboxamide

6,9-dibromo-2-trityl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

[8-bromo-4-(2-trimethylsilanyl-ethoxymethyl)-1,2,3,4-tetrahydro-cyclopenta[b]indol-5-yl]-phenyl-methanol

Refernces

• 1、 Martin, Corey R.,Leith, Gabrielle A.,Kittikhunnatham, Preecha,Park, Kyoung Chul,Ejegbavwo, Otega A.,Mathur, Abhijai,Callahan, Cameron R.,Desmond, Shelby L.,Keener, Myles R.,Ahmed, Fiaz,Pandey, Shubham,Smith, Mark D.,Phillpot, Simon R.,Greytak, Andrew B.,Shustova, Natalia B.. "Heterometallic Actinide-Containing Photoresponsive Metal-Organic Frameworks: Dynamic and Static Tuning of Electronic Properties". supporting information. p. 8072 - 8080. Retrieved 2021/03/01.
• 2、 Vukov, Darko J.,Gibson, Martin S.,Lee, William E.,Richardson, Mary F.. "Synthesis and reactions of 1H-4,1,2-benzothiadiazines, and observations on the structure of hydrazonoyl sulphides". . p. 192 - 196. Retrieved 2007/10/05.