5-methyl-2-(4-methyl-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-2,4-dihydro-3H-pyrazol-3-one

Base Information

• Chemical Name: 5-methyl-2-(4-methyl-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-2,4-dihydro-3H-pyrazol-3-one
• CAS No.: 107089-85-0
• Molecular Formula: C₁₂H₁₂N₄O₃S
• Molecular Weight: 292.318
• Mol file: 107089-85-0.mol

Synonyms:3H-Pyrazol-3-one,2,4-dihydro-5-methyl-2-(4-methyl-4H-1,2,4-benzothiadiazin-3-yl)-, S,S-dioxide;4H-1,2,4-Benzothiadiazine, 3H-pyrazol-3-one deriv.; NSC 373871

Chemical Property of 5-methyl-2-(4-methyl-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-2,4-dihydro-3H-pyrazol-3-one

Chemical Property:

• Vapor Pressure: 5.22E-09mmHg at 25°C
• Boiling Point: 470.1°Cat760mmHg
• Flash Point: 238.1°C
• Density: 1.56g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methyl-2-(4-methyl-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-2,4-dihydro-3H-pyrazol-3-one

There total 3 articles about 5-methyl-2-(4-methyl-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-2,4-dihydro-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

ethyl acetoacetate (141-97-9) + NSC 373858 (107089-79-2) → 3-(3'-methyl-5'-pyrazolonyl)-4-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide (107089-85-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 4h; Heating;

Reference yield:

3,4-Dihydro-4-methyl-2H-1,2,4-benzothiadiazin-3-on-1,1-dioxid (13338-02-8) → 3-(3'-methyl-5'-pyrazolonyl)-4-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide (107089-85-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / PCl₅ / 1.5 h / 200 - 210 °C

2: 81 percent / hydrazine hydrate (98percent) / CHCl₃ / 0.5 h / Ambient temperature

3: 46 percent / hydrochloric acid / ethanol / 4 h / Heating

With hydrogenchloride; phosphorus pentachloride; hydrazine hydrate; In ethanol; chloroform;

Reference yield:

NSC 373853 (107089-76-9) → 3-(3'-methyl-5'-pyrazolonyl)-4-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide (107089-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / hydrazine hydrate (98percent) / CHCl₃ / 0.5 h / Ambient temperature

2: 46 percent / hydrochloric acid / ethanol / 4 h / Heating

With hydrogenchloride; hydrazine hydrate; In ethanol; chloroform;

upstream raw materials:

ethyl acetoacetate

NSC 373858

3,4-Dihydro-4-methyl-2H-1,2,4-benzothiadiazin-3-on-1,1-dioxid

NSC 373853