1-(3,4-Dimethoxyphenyl)-2-hydroxy-2-phenylethan-1-one

Base Information

Chemical Name:1-(3,4-Dimethoxyphenyl)-2-hydroxy-2-phenylethan-1-one
CAS No.:62762-70-3
Molecular Formula:C16H16O4
Molecular Weight:272.301
Hs Code.:
DSSTox Substance ID:DTXSID10492715

Synonyms:3,4-dimethoxybenzoin;62762-70-3;1-(3,4-Dimethoxyphenyl)-2-hydroxy-2-phenylethan-1-one;DTXSID10492715

Suppliers and Price of 1-(3,4-Dimethoxyphenyl)-2-hydroxy-2-phenylethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,4-Dimethoxyphenyl)-2-hydroxy-2-phenylethan-1-one

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:272.10485899
Heavy Atom Count:20
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C(=O)C(C2=CC=CC=C2)O)OC

Technology Process of 1-(3,4-Dimethoxyphenyl)-2-hydroxy-2-phenylethan-1-one

There total 3 articles about 1-(3,4-Dimethoxyphenyl)-2-hydroxy-2-phenylethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1569272-05-4
(2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl)(phenyl)methanol

: 62762-70-3
1-(3,4-dimethoxyphenyl)-2-hydroxy-2-phenylethanone

Guidance literature:: With N-chloro-succinimide; silver nitrate; In water; acetonitrile; at 20 ℃;
DOI:10.1021/ol500292c

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 62762-70-3
1-(3,4-dimethoxyphenyl)-2-hydroxy-2-phenylethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

2.2: 1 h / -78 °C

3.1: N-chloro-succinimide; silver nitrate / acetonitrile; water / 20 °C

With N-chloro-succinimide; n-butyllithium; boron trifluoride diethyl etherate; silver nitrate; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/ol500292c

Reference yield:

: 50766-67-1
2-(3,4-dimethoxyphenyl)-1,3-dithiane

: 62762-70-3
1-(3,4-dimethoxyphenyl)-2-hydroxy-2-phenylethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

1.2: 1 h / -78 °C

2.1: N-chloro-succinimide; silver nitrate / acetonitrile; water / 20 °C

With N-chloro-succinimide; n-butyllithium; silver nitrate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ol500292c