1H-indol-2-yl(4-{3-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl}piperazin-1-yl)methanone

Base Information

Chemical Name:1H-indol-2-yl(4-{3-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl}piperazin-1-yl)methanone
CAS No.:136816-92-7
Molecular Formula:C20H20F3N5O
Molecular Weight:403.4009
Hs Code.:
Mol file:136816-92-7.mol

Synonyms:1-(Indolyl-2-carbonyl)-4-(3-((2,2,2-trifluoroethyl)amino)-2-pyridyl)piperazine;Piperazine,1-(1H-indol-2-ylcarbonyl)-4-(3-((2,2,2-trifluoroethyl)amino)-2-pyridinyl);

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-indol-2-yl(4-{3-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl}piperazin-1-yl)methanone

Chemical Property:

Vapor Pressure:9.44E-15mmHg at 25°C
Boiling Point:608.5°Cat760mmHg
PKA:16.11±0.30(Predicted)
Flash Point:321.8°C
PSA：64.26000
Density:1.401g/cm³
LogP:3.57540

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-indol-2-yl(4-{3-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl}piperazin-1-yl)methanone

There total 4 articles about 1H-indol-2-yl(4-{3-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl}piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 136818-73-0
1-<3-<(2,2,2-trifluoroethyl)amino>-2-pyridyl>piperazine

: 136816-92-7
1-(indolyl-2-carbonyl)-4-<3-<(2,2,2-trifluoroethyl)amino>-2-pyridyl>piperazine

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 136818-71-8
1-<(benzyloxy)carbonyl>-4-<3-(2,2,2-trifluoroacetamido)-2-pyridyl>piperazine

: 136816-92-7
1-(indolyl-2-carbonyl)-4-<3-<(2,2,2-trifluoroethyl)amino>-2-pyridyl>piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / H₂ / 10percent Pd/C / ethanol / 20 h / 2068.6 Torr

2: 72 percent / LAH / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 45 min

3: 55 percent / EDC / tetrahydrofuran; dimethylformamide

With lithium aluminium tetrahydride; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 136818-72-9
1-<3-(2,2,2-trifluoroacetamido)-2-pyridyl>piperazine

: 136816-92-7
1-(indolyl-2-carbonyl)-4-<3-<(2,2,2-trifluoroethyl)amino>-2-pyridyl>piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / LAH / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 45 min

2: 55 percent / EDC / tetrahydrofuran; dimethylformamide

With lithium aluminium tetrahydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;