Tyrphostin AG 555

Base Information

Chemical Name:Tyrphostin AG 555
CAS No.:133550-34-2
Molecular Formula:C19H18N2O3
Molecular Weight:322.364
Hs Code.:
DSSTox Substance ID:DTXSID401017644
Nikkaji Number:J1.175.356F,J412.914H
NCI Thesaurus Code:C1675
ChEMBL ID:CHEMBL53898
Mol file:133550-34-2.mol

Synonyms:AG 555;AG-555;alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide;N-(3'-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide;N-(3-phenylpropyl)-3,4-dihydroxybenzylidene cyanoacetamide;tyrphostin AG 555;tyrphostin AG-555;tyrphostin B46

Suppliers and Price of Tyrphostin AG 555

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AG 555
10mg
$ 389.00

TRC
AG555
10mg
$ 275.00

Tocris
AG555 ≥99%(HPLC)
10
$ 110.00

Tocris
AG555 ≥99%(HPLC)
50
$ 462.00

DC Chemicals
TyrphostinAG-555 >98%
100 mg
$ 400.00

DC Chemicals
TyrphostinAG-555 >98%
1 g
$ 1300.00

ChemScene
AG555 ≥98.0%
250mg
$ 700.00

ChemScene
AG555 ≥98.0%
100mg
$ 400.00

Cayman Chemical
AG-555 ≥95%
50mg
$ 285.00

Cayman Chemical
AG-555 ≥95%
25mg
$ 162.00

Total 17 raw suppliers

Chemical Property of Tyrphostin AG 555

Chemical Property:

Vapor Pressure:5.09E-16mmHg at 25°C
Refractive Index:1.649
Boiling Point:621.1 °C at 760 mmHg
PKA:8.82±0.10(Predicted)
Flash Point:329.4 °C
PSA：93.35000
Density:1.273 g/cm³
LogP:3.14468
Storage Temp.:−20°C
Solubility.:DMSO or ethanol: soluble
XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:322.13174244
Heavy Atom Count:24
Complexity:488

Purity/Quality:

99%, ^*data from raw suppliers

AG 555 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCCNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
Isomeric SMILES:C1=CC=C(C=C1)CCCNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
Description AG-555 is a tyrphostin inhibitor of the EGF receptor (EGFR; IC50 = 0.7 μM). It selectively inhibits EFGR over ErbB2 (IC50 = 35 μM). AG-555 inhibits EGF-dependent growth of HER 14 cells (IC50 = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis when used at concentrations ranging from 1 to 50 μM. It also inhibits Moloney murine leukemia virus (Mo-MuLV) reverse transcriptase activity (IC50 = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC50 = 210 μM).
Uses Inhibitor of EGF receptor kinase activity

Technology Process of Tyrphostin AG 555

There total 2 articles about Tyrphostin AG 555 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%