Technology Process of 2-Propenoic acid, 3-[5-(4-chlorophenyl)-2-furanyl]-, (E)-
There total 14 articles about 2-Propenoic acid, 3-[5-(4-chlorophenyl)-2-furanyl]-, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
piperidine; pyridine;
for 4h;
Heating;
- Guidance literature:
-
With
phenylalanine ammonia-lyase;
at 30 ℃;
for 168h;
pH=8.8;
optical yield given as %ee;
enantioselective reaction;
aq. buffer;
Inert atmosphere;
Enzymatic reaction;
DOI:10.3987/COM-10-S(E)60
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / methanol / 20 °C
2.1: thionyl chloride; benzotriazol-1-ol / dichloromethane
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere
3.2: 20 - 60 °C
4.1: water; sodium hydroxide / methanol / 20 h / 20 °C
5.1: toluene / 2 h / Reflux
6.1: hydrogenchloride / 1,4-dioxane / 4 h / Reflux
7.1: phenylalanine ammonia-lyase / 168 h / 30 °C / pH 8.8 / aq. buffer; Inert atmosphere; Enzymatic reaction
With
hydrogenchloride; sodium tetrahydroborate; thionyl chloride; phenylalanine ammonia-lyase; water; sodium hydride; benzotriazol-1-ol; sodium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.3987/COM-10-S(E)60
