3-(4-Chlorophenyl)-5-phenyl-1,3-oxazol-2(3H)-one

Base Information

Chemical Name:3-(4-Chlorophenyl)-5-phenyl-1,3-oxazol-2(3H)-one
CAS No.:62812-44-6
Molecular Formula:C15H10ClNO2
Molecular Weight:271.703
Hs Code.:
DSSTox Substance ID:DTXSID90490754
Nikkaji Number:J2.576.983J
Wikidata:Q82334730

Synonyms:62812-44-6;3-(4-Chlorophenyl)-5-phenyl-1,3-oxazol-2(3H)-one;DTXSID90490754

Suppliers and Price of 3-(4-Chlorophenyl)-5-phenyl-1,3-oxazol-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-(4-Chlorophenyl)-5-phenyl-1,3-oxazol-2(3H)-one

Chemical Property:

Melting Point:197-198 °C(Solv: 1,4-dioxane (123-91-1))
Boiling Point:414.6±55.0 °C(Predicted)
PSA：35.14000
Density:1.365±0.06 g/cm3(Predicted)
LogP:3.75090
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:271.0400063
Heavy Atom Count:19
Complexity:368

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CN(C(=O)O2)C3=CC=C(C=C3)Cl

Technology Process of 3-(4-Chlorophenyl)-5-phenyl-1,3-oxazol-2(3H)-one

There total 4 articles about 3-(4-Chlorophenyl)-5-phenyl-1,3-oxazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1011269-15-0
(4-chlorophenyl)-phenylethynyl-carbamic acid tert-butyl ester

: 62812-44-6
3-(4-chloro-phenyl)-5-phenyl-3H-oxazol-2-one

Guidance literature:: With silver tetrafluoroborate; In dichloromethane; at 20 ℃; for 18h;
DOI:10.3987/COM-18-S(F)21

Reference yield: 72.0%

: benzyl N-(4-chlorophenyl)-N-(2-phenylethynyl)carbamate

: 62812-44-6
3-(4-chloro-phenyl)-5-phenyl-3H-oxazol-2-one

Guidance literature:: With zinc(II) chloride; In dichloromethane; at 40 ℃; for 4h; Inert atmosphere;
DOI:10.1002/ejoc.201900428

Reference yield:

: 6622-16-8
benzyl (4-chlorophenyl)carbamate

: 62812-44-6
3-(4-chloro-phenyl)-5-phenyl-3H-oxazol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium phosphate / toluene / 80 °C / Inert atmosphere

2: zinc(II) chloride / dichloromethane / 4 h / 40 °C / Inert atmosphere

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; zinc(II) chloride; In dichloromethane; toluene;
DOI:10.1002/ejoc.201900428