Glycine, N-[1-(4-methoxyphenyl)-2-[[(4-methylphenyl)methyl]thio]ethyl]-

Base Information

Chemical Name:Glycine, N-[1-(4-methoxyphenyl)-2-[[(4-methylphenyl)methyl]thio]ethyl]-
CAS No.:628298-45-3
Molecular Formula:C19H23NO3S
Molecular Weight:345.463
Hs Code.:
DSSTox Substance ID:DTXSID60457778

Synonyms:628298-45-3;Glycine, N-[1-(4-methoxyphenyl)-2-[[(4-methylphenyl)methyl]thio]ethyl]-;DTXSID60457778

Suppliers and Price of Glycine, N-[1-(4-methoxyphenyl)-2-[[(4-methylphenyl)methyl]thio]ethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycine, N-[1-(4-methoxyphenyl)-2-[[(4-methylphenyl)methyl]thio]ethyl]-

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:345.13986477
Heavy Atom Count:24
Complexity:364

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)CSCC(C2=CC=C(C=C2)OC)NCC(=O)O

Technology Process of Glycine, N-[1-(4-methoxyphenyl)-2-[[(4-methylphenyl)methyl]thio]ethyl]-

There total 10 articles about Glycine, N-[1-(4-methoxyphenyl)-2-[[(4-methylphenyl)methyl]thio]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 628298-44-2
rac-[1-(4-methoxyphenyl)-2-(4-methylbenzylsulfanyl)ethylamino]acetic acid ethyl ester

: 628298-45-3
rac-[1-(4-methoxyphenyl)-2-(4-methylbenzylsulfanyl)ethylamino]acetic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 17h;
DOI:10.1021/jo049471k

Reference yield: 75.0%

: 298-12-4
Glyoxilic acid

: 403739-55-9
rac-1-(4-methoxyphenyl)-2-(4-methylbenzylsulfanyl)ethylamine

: 628298-45-3
rac-[1-(4-methoxyphenyl)-2-(4-methylbenzylsulfanyl)ethylamino]acetic acid

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃; for 24h;
DOI:10.1021/jo049471k

Reference yield:

: 4498-99-1
4-methylbenzylthiol

: 628298-45-3
rac-[1-(4-methoxyphenyl)-2-(4-methylbenzylsulfanyl)ethylamino]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / DIEA / dimethylformamide / 4 h / 20 °C

2: 87 percent / pyridine / ethanol / 2 h / Heating

3: 80 percent / BH₃*THF / tetrahydrofuran / 3.5 h / Heating

4: 75 percent / sodium cyanoborohydride; HCl / methanol / 24 h / 20 °C

With pyridine; hydrogenchloride; borane-THF; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo049471k