N-(4-Chloro-5-phenyl-3-isoxazolyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(4-Chloro-5-phenyl-3-isoxazolyl)-2,2,2-trifluoroacetamide
CAS No.:62847-51-2
Molecular Formula:C₁₁H₆ClF₃N₂O₂
Molecular Weight:290.629
Hs Code.:
ChEMBL ID:CHEMBL3276969
DSSTox Substance ID:DTXSID601190296

Synonyms:CHEMBL3276969;DTXSID601190296;N-(4-Chloro-5-phenyl-3-isoxazolyl)-2,2,2-trifluoroacetamide;62847-51-2

Suppliers and Price of N-(4-Chloro-5-phenyl-3-isoxazolyl)-2,2,2-trifluoroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Chloro-5-phenyl-3-isoxazolyl)-2,2,2-trifluoroacetamide

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:290.0069896
Heavy Atom Count:19
Complexity:334

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(C(=NO2)NC(=O)C(F)(F)F)Cl

Technology Process of N-(4-Chloro-5-phenyl-3-isoxazolyl)-2,2,2-trifluoroacetamide

There total 2 articles about N-(4-Chloro-5-phenyl-3-isoxazolyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62847-46-5
2,2,2-trifluoro-N-(5-phenyl-isoxazol-3-yl)-acetamide

: 62847-51-2
N-(4-chloro-5-phenyl-isoxazol-3-yl)-2,2,2-trifluoro-acetamide

Guidance literature:: With sulfuryl dichloride; for 0.333333h;
DOI:10.1021/jm00217a014

Reference yield:

: 6455-31-8
3-amino-5-phenylisoxazole

: 62847-51-2
N-(4-chloro-5-phenyl-isoxazol-3-yl)-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: Py / 1 h

2: SO₂Cl₂ / 0.33 h

With pyridine; sulfuryl dichloride;
DOI:10.1021/jm00217a014