2-Acetyl-4(3H)-quinazolinone

Base Information

• Chemical Name: 2-Acetyl-4(3H)-quinazolinone
• CAS No.: 17244-28-9
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.186
• Hs Code.: 2933990090
• Mol file: 17244-28-9.mol

Synonyms:2-Acetyl-3H-chinazolon-(4);2-Acetylquinazolin-4(3H)-one;2-Acetyl-4(3H)-quinazolinone;2-acetyl-4(3H)quinazoline;2-acetyl-3H-quinazolin-4-one;2-acetyl-4(3H)-quinazolidinone;2-Quinazolin-4(3H)-one;4(3H)-Quinazolinone,2-acetyl;

Chemical Property of 2-Acetyl-4(3H)-quinazolinone

Chemical Property:

• Vapor Pressure: 3.1E-05mmHg at 25°C
• Melting Point: 205 °C(Solv: ethanol (64-17-5))
• Boiling Point: 355.5°Cat760mmHg
• PKA: -2.25±0.20(Predicted)
• Flash Point: 168.8°C
• PSA: 62.82000
• Density: 1.34g/cm³
• LogP: 1.12570
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Acetylquinazolin-4(3H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acetyl-4(3H)-quinazolinone

There total 12 articles about 2-Acetyl-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-[2-Oxo-1-(triphenyl-λ5-phosphanylidene)-propyl]-1,2-dihydro-indazol-3-one (103748-75-0) → 2-acetyl-4-oxo-dihydroquinazoline (17244-28-9) + triphenylphosphine (603-35-0)

Guidance literature:

In toluene; at 95 ℃; for 2h;

DOI:10.1016/S0040-4020(01)96683-9

Reference yield: 79.0%

2-(α,α-Dichloropropionyl)aminobenzamide (129768-47-4) → 2-acetyl-4(3H)-quinazolidinone (17244-28-9)

Guidance literature:

With sodium hydroxide; In ethanol; at 70 ℃; for 1h;

DOI:10.1016/S0040-4020(01)86694-1

Reference yield: 65.0%

2-(2-oxopropanamido)benzamide (18326-62-0) → 2-acetyl-4(3H)-quinazolidinone (17244-28-9)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 0.00166667h;

DOI:10.1016/j.bmcl.2020.127550

upstream raw materials:

2-(α,α-Dichloropropionyl)aminobenzamide

(-)-(S)-2-(α-Hydroxyethyl)-4(3H)-quinazolinone

2-oxo-propionic acid

anthranilic acid amide

Downstream raw materials:

(-)-(S)-2-(α-Hydroxyethyl)-4(3H)-quinazolinone

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-(4-oxo-3,4-dihydro-quinazolin-2-yl)-ethyl ester