1-Piperidinecarboxylic acid, 2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]ethyl]-4-oxo-, phenylmethyl ester, (2R)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]ethyl]-4-oxo-, phenylmethyl ester, (2R)-
CAS No.:629648-08-4
Molecular Formula:C26H42N2O6Si
Molecular Weight:506.715
Hs Code.:

1-Piperidinecarboxylic acid,
2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(1,1-dimethylethyl)di
methylsilyl]oxy]ethyl]-4-oxo-, phenylmethyl ester, (2R)-

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]ethyl]-4-oxo-, phenylmethyl ester, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]ethyl]-4-oxo-, phenylmethyl ester, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]ethyl]-4-oxo-, phenylmethyl ester, (2R)-

There total 2 articles about 1-Piperidinecarboxylic acid, 2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]ethyl]-4-oxo-, phenylmethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 100-46-9
benzylamine

: 629648-04-0
(6S)-7-(tert-butyldimethylsilyloxy)-6-(tert-butoxycarbonylamino)-1-(p-toluenesulfonyl)-4-hepten-3-one

: 629648-08-4
(1S,2'R)-1-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-2-(tert-butyldimethylsilyloxy)ethylcarbamic acid tert-butyl ester

: 629648-13-1
(1S,2'S)-1-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-2-(tert-butyldimethylsilyloxy)ethylcarbamic acid tert-butyl ester

Guidance literature:: benzylamine; (6S)-7-(tert-butyldimethylsilyloxy)-6-(tert-butoxycarbonylamino)-1-(p-toluenesulfonyl)-4-hepten-3-one; In tetrahydrofuran; at 0 ℃; for 120h;

With palladium dihydroxide; hydrogen; In methanol; at 25 ℃; for 20h; under 2585.74 Torr;

benzyl chloroformate; With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2003.08.060

Reference yield:

: 124085-68-3
tert-butyl (R)-1-(tert-butyldimethylsilyloxy)-3-oxopropan-2-yl carbamate

: 629648-08-4
(1S,2'R)-1-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-2-(tert-butyldimethylsilyloxy)ethylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / CHCl₃ / 30 h / 25 °C

2.1: tetrahydrofuran / 120 h / 0 °C

2.2: H₂; Pd(OH)2 / methanol / 20 h / 25 °C / 2585.74 Torr

2.3: 0.20 g / Na₂CO₃*10H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

In tetrahydrofuran; chloroform; 1.1: Wittig reaction / 2.1: Michael reaction;
DOI:10.1016/j.tet.2003.08.060