methyl 8-hydroxy-12-oxoabiet-13-en-18-oate

Base Information

• Chemical Name: methyl 8-hydroxy-12-oxoabiet-13-en-18-oate
• CAS No.: 7501-48-6
• Molecular Formula: C₂₁H₃₂O₄
• Molecular Weight: 348.483

Synonyms:5x,8x,9x,10x-Podocarp-13-en-15(or16)-oic acid, 8-hydroxy-13-isopropyl-12-oxo-, methylester (8CI); NSC 406628

Chemical Property of methyl 8-hydroxy-12-oxoabiet-13-en-18-oate

Chemical Property:

• Vapor Pressure: 3.1E-10mmHg at 25°C
• Boiling Point: 456.1°Cat760mmHg
• Flash Point: 151.6°C
• Density: 1.113g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

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Technology Process of methyl 8-hydroxy-12-oxoabiet-13-en-18-oate

There total 4 articles about methyl 8-hydroxy-12-oxoabiet-13-en-18-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 8,12α-epidioxy-13-abietan-18-oate (5309-31-9,55528-88-6) → methyl 8α-hydroxy-12-oxo-13-abietan-18-oate (3787-85-7,7501-48-6,61597-76-0)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.166667h; Heating;

DOI:10.1016/0031-9422(91)83732-Z

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 12-Oxo-8-hydroxy abiet-13(14)-enoic acid (115911-97-2,130252-62-9) → methyl 8α-hydroxy-12-oxo-13-abietan-18-oate (3787-85-7,7501-48-6,61597-76-0)

Guidance literature:

In diethyl ether;

DOI:10.1016/0031-9422(90)85223-3

Reference yield:

→ Methyl-Δ13(14)-8α-hydroxy-12-keto-abietenoat (3787-85-7,7501-48-6,61597-76-0)

Guidance literature:

Δ⁸⁽¹⁴⁾-12α-Hydroxy-13αH-abietensaeure-methylester, Oxidation nach Dauben, Coates, J.Org.Chem. 28 <1963> 1698;

upstream raw materials:

diazomethane

12-Oxo-8-hydroxy abiet-13⁽¹⁴⁾-enoic acid

methyl 8,12α-epidioxy-13-abietan-18-oate

Downstream raw materials:

(1R,4aR)-7-Isopropyl-1,4a-dimethyl-6-oxo-1,2,3,4,4a,4b,5,6,10,10a-decahydro-phenanthrene-1-carboxylic acid methyl ester

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