Technology Process of Carbamic acid, diphenyl-,
2-(acetylamino)-9-[(2R,5S,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1
-thiaspiro[4.4]non-2-yl]-9H-purin-6-yl ester
There total 11 articles about Carbamic acid, diphenyl-,
2-(acetylamino)-9-[(2R,5S,6R)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1
-thiaspiro[4.4]non-2-yl]-9H-purin-6-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N2-acetyl-O6-(diphenylcarbamoyl)guanine;
With
trimethylsilyl trifluoromethanesulfonate; triethylamine;
In
toluene;
for 0.333333h;
tert-Butyl-dimethyl-((5S,6R)-1-oxo-1λ4-thia-spiro[4.4]non-6-yloxy)-silane;
With
zinc(II) iodide;
In
toluene;
for 48h;
DOI:10.1021/jo030196w
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 37 percent / Sc(OTf)3 / CH2Cl2; acetonitrile / 48 h / Heating
2.1: 91 percent / H2 / Pd/C / ethyl acetate / 48 h / 20 °C / 760 Torr
3.1: 100 percent / LiOH / tetrahydrofuran; H2O / 4 h
4.1: 34 percent / LiAlH4 / diethyl ether / 4 h
5.1: 95 percent / 2,6-lutidine / CH2Cl2 / 0 - 20 °C
6.1: 95 percent / NaIO4/SiO2 / CH2Cl2; hexane / 12 h
7.1: Et3N; TMSOTf / toluene / 0.33 h
7.2: 13 percent / ZnI2 / toluene / 48 h
With
2,6-dimethylpyridine; lithium hydroxide; sodium periodate; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; hydrogen; silica gel; triethylamine; scandium tris(trifluoromethanesulfonate);
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jo030196w
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 91 percent / H2 / Pd/C / ethyl acetate / 48 h / 20 °C / 760 Torr
2.1: 100 percent / LiOH / tetrahydrofuran; H2O / 4 h
3.1: 34 percent / LiAlH4 / diethyl ether / 4 h
4.1: 95 percent / 2,6-lutidine / CH2Cl2 / 0 - 20 °C
5.1: 95 percent / NaIO4/SiO2 / CH2Cl2; hexane / 12 h
6.1: Et3N; TMSOTf / toluene / 0.33 h
6.2: 13 percent / ZnI2 / toluene / 48 h
With
2,6-dimethylpyridine; lithium hydroxide; sodium periodate; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; hydrogen; silica gel; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1021/jo030196w
