Benzamide, 3,3'-(1,3,4-oxadiazole-2,5-diyl)bis[N-[(1S)-1-(chloromethyl)-2-phenyleth yl]-

Base Information

• Chemical Name: Benzamide, 3,3'-(1,3,4-oxadiazole-2,5-diyl)bis[N-[(1S)-1-(chloromethyl)-2-phenyleth yl]-
• CAS No.: 630106-27-3
• Molecular Formula: C34H30Cl2N4O3
• Molecular Weight: 613.543
• Mol file: 630106-27-3.mol

Synonyms:

Chemical Property of Benzamide, 3,3'-(1,3,4-oxadiazole-2,5-diyl)bis[N-[(1S)-1-(chloromethyl)-2-phenyleth yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, 3,3'-(1,3,4-oxadiazole-2,5-diyl)bis[N-[(1S)-1-(chloromethyl)-2-phenyleth yl]-

There total 3 articles about Benzamide, 3,3'-(1,3,4-oxadiazole-2,5-diyl)bis[N-[(1S)-1-(chloromethyl)-2-phenyleth yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,5-bis[m-[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)amido]phenyl]-1,3,4-oxadiazole (630106-23-9) → 2,5-bis[m-[N-(1'S)-(1'-benzyl-2'-chloroethyl)amido]phenyl]-1,3,4-oxadiazole (630106-27-3)

Guidance literature:

With thionyl chloride; In dichloromethane; for 5h; Heating;

DOI:10.1081/SCC-120021848

Reference yield:

3,3'-(1,3,4-oxadiazole-2,5-diyl)dibenzoic acid (2425-93-6) → 2,5-bis[m-[N-(1'S)-(1'-benzyl-2'-chloroethyl)amido]phenyl]-1,3,4-oxadiazole (630106-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 10 h / Heating

2: 1.24 g / Et₃N / CH₂Cl₂ / 24 h / 20 °C

3: 69 percent / SOCl₂ / CH₂Cl₂ / 5 h / Heating

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1081/SCC-120021848

Reference yield:

3,3'-[1,3,4]oxadiazole-2,5-diyl-bis-benzoyl chloride (4416-76-6) → 2,5-bis[m-[N-(1'S)-(1'-benzyl-2'-chloroethyl)amido]phenyl]-1,3,4-oxadiazole (630106-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.24 g / Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 69 percent / SOCl₂ / CH₂Cl₂ / 5 h / Heating

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1081/SCC-120021848

upstream raw materials:

2,5-bis[m-[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)amido]phenyl]-1,3,4-oxadiazole

3,3'-(1,3,4-oxadiazole-2,5-diyl)dibenzoic acid

3,3'-[1,3,4]oxadiazole-2,5-diyl-bis-benzoyl chloride

Refernces