(2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid

Base Information

Chemical Name:(2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid
CAS No.:630421-46-4
Molecular Formula:C16H28N2O6
Molecular Weight:344.408
Hs Code.:
Mol file:630421-46-4.mol

Synonyms:N-([(1,1-dimethylethyl)oxy]carbonyl)-3-methyl-L-valyl-(4R)-4-hydroxy-L-proline;

Suppliers and Price of (2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Ambeed
(2S,4R)-1-((S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid 95%
5g
$ 154.00

Ambeed
(2S,4R)-1-((S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid 95%
1g
$ 41.00

Ambeed
(2S,4R)-1-((S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid 95%
250mg
$ 17.00

Ambeed
(2S,4R)-1-((S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid 95%
100mg
$ 11.00

Acrotein
1-(Boc-L-tert-leucinyl)-(4R)-4-hydroxy-L-proline 97%
1g
$ 275.00

Abosyn
(2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid 95%-98%
1g
$ 300.00

A1 Biochem Labs
(2S,4R)-1-{(S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl}-4-hydroxy-pyrrolidine-2-carboxylicacid 95%
5 g
$ 1100.00

Total 18 raw suppliers

Chemical Property of (2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid

Chemical Property:

PSA：116.17000
LogP:1.30100

Purity/Quality:

97% ^*data from raw suppliers

(2S,4R)-1-((S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid

There total 2 articles about (2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 630421-46-4
(2S,4R)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxylic acid

Guidance literature:: N-tert-butyloxycarbonyl-L-tert-leucine; L-4-hydroxyproline methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

With water; lithium hydroxide; In tetrahydrofuran;

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 630421-46-4
(2S,4R)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: HATU / dichloromethane / 0.25 h / 20 °C

1.2: 15 h / 0 - 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 72 h / 20 °C

2.2: pH 4

With lithium hydroxide monohydrate; water; HATU; In tetrahydrofuran; methanol; dichloromethane;

Reference yield: 98.0%

: 630421-46-4
(2S,4R)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxylic acid

: C₂₉H₂₉N₃O₃S

: C₄₅H₅₅N₅O₈S

Guidance literature:: (2S,4R)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

C₂₉H₂₉N₃O₃S; In N,N-dimethyl-formamide; at 20 ℃; for 2h;