Toluene-4-sulfonic acid 2-cyclopropyl-ethyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid 2-cyclopropyl-ethyl ester
• CAS No.: 63064-31-3
• Molecular Formula: C12H16O3S
• Molecular Weight: 240.323
• Hs Code.: 2906199090
• Mol file: 63064-31-3.mol

Synonyms:2-cyclopropylethyl toluene-4-sulfonate;2-Cyclopropylethyl 4-methylbenzenesulfonate;TOLUENE-4-SULFONIC ACID 2-CYCLOPROPYL-ETHYL ESTER;toluene-4-sulfonic acid 2-cyclopropylethyl ester;2-cyclopropylethyl tosylate;

Chemical Property of Toluene-4-sulfonic acid 2-cyclopropyl-ethyl ester

Chemical Property:

• PSA: 51.75000
• LogP: 3.58120

Purity/Quality:

97% ^*data from raw suppliers

Toluene-4-sulfonicacid2-cyclopropyl-ethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid 2-cyclopropyl-ethyl ester

There total 2 articles about Toluene-4-sulfonic acid 2-cyclopropyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-cyclopropylethanol (2566-44-1) + p-toluenesulfonyl chloride (98-59-9) → 4-methylphenyl sulfonic acid (2-cyclopropylethyl) ester (63064-31-3)

Guidance literature:

With pyridine; In dichloromethane; for 16h;

Reference yield: 92.7%

1-cyclopropylethanol (2566-44-1) + toluene-4-sulfonic acid (104-15-4) → 4-methylphenyl sulfonic acid (2-cyclopropylethyl) ester (63064-31-3)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 95.0%

4-methylphenyl sulfonic acid (2-cyclopropylethyl) ester (63064-31-3) + (S)-methyl 2-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)benzoate → (S)-methyl 2-(3-(2-cyclopropylethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)-benzoate

Guidance literature:

(S)-methyl 2-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)benzoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;

4-methylphenyl sulfonic acid (2-cyclopropylethyl) ester; In N,N-dimethyl-formamide; mineral oil; at 0 - 50 ℃; for 22h;

DOI:10.1016/j.bmc.2013.10.023

upstream raw materials:

1-cyclopropylethanol

p-toluenesulfonyl chloride

toluene-4-sulfonic acid

Downstream raw materials:

cyclopentyl formate

formate ester of 4-penten-2-ol

N-benzyl-5-(4-(2-cyclopropylethoxy)-2-oxopyridin-1(2H)-yl)-3-methylthiophene-2-carboxamide

C₃₀H₃₅N₃O₆