AC-DEVD-CHO

Base Information

• Chemical Name: AC-DEVD-CHO
• CAS No.: 169332-60-9
• Molecular Formula: C₂₀H₃₀N₄O₁₁
• Molecular Weight: 502.478
• Mol file: 169332-60-9.mol

Synonyms:L-Valinamide,N-acetyl-L-a-aspartyl-L-a-glutamyl-N-(2-carboxy-1-formylethyl)-,(S)-;17: PN: WO2005039629 PAGE: 18 claimed protein;1: PN: WO0009664 PAGE: 33claimed protein;4: PN: WO0158526 SEQID: 4 claimed sequence;L 761191;MF 191;

Chemical Property of AC-DEVD-CHO

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 1021.1°Cat760mmHg
• PKA: 4.19±0.10(Predicted)
• Flash Point: 571.3°C
• PSA: 245.37000
• Density: 1.374g/cm³
• LogP: -0.82180
• Storage Temp.: −20°C
• Sensitive.: Moisture Sensitive
• Solubility.: H2O: 1 mg/mL

Purity/Quality:

99% ^*data from raw suppliers

^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Technology Process of AC-DEVD-CHO

There total 1 articles about AC-DEVD-CHO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-allyloxycarbonyl-4-amino-5-benzyloxy-2-oxotetrahydrofuran + water (7732-18-5) → (4S)-4-[(2S)-3-carboxy-2-acetamidopropanamido]-4-{[(1S)-1-[(1-carboxy-3-oxopropan-2-yl)carbamoyl]-2-methylpropyl]carbamoyl}butanoic acid (184179-08-6,169332-60-9)

Guidance literature:

With acetic acid; Pd(OH)2; In methanol;

upstream raw materials:

water

Refernces

Synthesis and activity evaluation of the cyclic dipeptides arylidene N-alkoxydiketopiperazines

10.1016/j.bmc.2016.08.038

This research presents the synthesis and activity evaluation of cyclic dipeptides arylidene N-alkoxydiketopiperazines (DKPs), which are biologically active natural products with potential applications in medicine due to their antimicrobial, antitumor, antiviral, and plant growth regulation properties. The study aimed to design and stereoselectively synthesize a series of arylidene N-alkoxy DKPs and assess their antitumor activities and inhibitory effects against caspase-3, a key enzyme in apoptosis. The synthesis involved the use of various benzylic halides, diethyl malonate, nano-K2CO3, EtONO, and other reagents to produce compounds with different aryl and alkyl substitutions. The conclusions drawn from the research indicated that most of the synthesized DKPs exhibited antitumor activity, with compounds 6d, 6f, 6l, and 6o showing higher potency against certain tumor cell lines. Particularly, compound 6o demonstrated significant antitumor activity against K562-1, HCT-15, and A549 cells, with IC50 values of 7.3, 8.6, and 11.4 μM, respectively.