n-acetyl-5-Methoxy-l-tryptophan

Base Information

• Chemical Name: n-acetyl-5-Methoxy-l-tryptophan
• CAS No.: 67010-09-7
• Molecular Formula: C14H16N2O4
• Molecular Weight: 276.292
• Hs Code.: 2933990090
• Mol file: 67010-09-7.mol

Synonyms:A-1476;2-(acetylamino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid;5-methoxy-Nb-acetyl-L-tryptophan;AmbotzAAA1951;

Chemical Property of n-acetyl-5-Methoxy-l-tryptophan

Chemical Property:

• Vapor Pressure: 1.12E-15mmHg at 25°C
• Boiling Point: 608.8°Cat760mmHg
• Flash Point: 322°C
• PSA: 91.42000
• Density: 1.321g/cm³
• LogP: 1.69920
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Acetamido-3-(5-methoxy-1H-indol-3-yl)propanoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of n-acetyl-5-Methoxy-l-tryptophan

There total 10 articles about n-acetyl-5-Methoxy-l-tryptophan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

acetic anhydride (108-24-7) + 5-methoxy-DL-tryptophan (25197-96-0) → Nα-acetyl-5-methoxy-L-tryptophan (67010-09-7,114926-33-9)

Guidance literature:

With acetic acid; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2008.02.120

Reference yield: 91.0%

5-methoxy-Nb-acetyl-L-tryptophan methyl ester (93272-00-5,114872-73-0,114872-83-2) → Nα-acetyl-5-methoxy-L-tryptophan (67010-09-7,114926-33-9)

Guidance literature:

With sodium hydroxide; In methanol; Ambient temperature;

Reference yield:

N-acetyl-L-proline methyl ester (2311-25-3,18800-83-4,27460-51-1,114376-47-5) → Nα-acetyl-5-methoxy-L-tryptophan (67010-09-7,114926-33-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Et₄NClO₄ / acetonitrile / Ambient temperature; anodic oxidation with Pt electrodes

2: 60 percent / AcOH / H₂O

3: 91 percent / 1 N NaOH / methanol / Ambient temperature

With sodium hydroxide; tetraethylammonium perchlorate; acetic acid; In methanol; water; acetonitrile;

upstream raw materials:

5-methoxy-N_b-acetyl-L-tryptophan methyl ester

N-acetyl-L-proline methyl ester

(S)-1-Acetyl-5-hydroxy-pyrrolidine-2-carboxylic acid methyl ester

L-proline

Downstream raw materials:

5-methoxy-L-tryptophan