L-Proline, 4-hydroxy-1-(phenylmethyl)-, trans-

Base Information

Chemical Name:L-Proline, 4-hydroxy-1-(phenylmethyl)-, trans-
CAS No.:63397-15-9
Molecular Formula:C12H15NO3
Molecular Weight:221.256
Hs Code.:
DSSTox Substance ID:DTXSID60422840
Nikkaji Number:J1.695.440C

Synonyms:L-Proline, 4-hydroxy-1-(phenylmethyl)-, trans-;N-benzyl-l-hydroxyproline;63397-15-9;SCHEMBL5067829;DTXSID60422840;1-Benzyl-trans-4-hydroxy-L-proline

Suppliers and Price of L-Proline, 4-hydroxy-1-(phenylmethyl)-, trans-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of L-Proline, 4-hydroxy-1-(phenylmethyl)-, trans-

Chemical Property:

XLogP3:-1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:221.10519334
Heavy Atom Count:16
Complexity:251

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(CN(C1C(=O)O)CC2=CC=CC=C2)O
Isomeric SMILES:C1[C@H](CN([C@@H]1C(=O)O)CC2=CC=CC=C2)O

Technology Process of L-Proline, 4-hydroxy-1-(phenylmethyl)-, trans-

There total 3 articles about L-Proline, 4-hydroxy-1-(phenylmethyl)-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 114676-48-1
(2S,4R)-1-benzyl-4-hydroxyproline methyl ester

: 63397-15-9
methyl (2S,4R)-1-benzyl-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃;
DOI:10.1039/c4ra13611j

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 63397-15-9
methyl (2S,4R)-1-benzyl-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / Reflux

2: triethylamine / chloroform / 6 h / Reflux

3: sodium hydroxide / water; tetrahydrofuran / 0 °C

With thionyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; chloroform; water;
DOI:10.1039/c4ra13611j

Reference yield:

: 1499-56-5,775275-31-5,790644-51-8,754962-86-2
(R)-4-hydroxy-L-proline ethyl ester

: 63397-15-9
methyl (2S,4R)-1-benzyl-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / chloroform / 6 h / Reflux

2: sodium hydroxide / water; tetrahydrofuran / 0 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran; chloroform; water;
DOI:10.1039/c4ra13611j