1,8-Naphthyridine-3-carboxylic acid, 7-(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl-1-[[4-(dimethylamino)phenyl] methyl]-6-fluoro-1,4-dihydro-4-oxo-

Base Information

Chemical Name:1,8-Naphthyridine-3-carboxylic acid, 7-(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl-1-[[4-(dimethylamino)phenyl] methyl]-6-fluoro-1,4-dihydro-4-oxo-
CAS No.:635308-46-2
Molecular Formula:C23H24FN5O3
Molecular Weight:437.474
Hs Code.:

1,8-Naphthyridine-3-carboxylic acid,
7-(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl-1-[[4-(dimethylamino)phenyl]
methyl]-6-fluoro-1,4-dihydro-4-oxo-

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Chemical Property of 1,8-Naphthyridine-3-carboxylic acid, 7-(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl-1-[[4-(dimethylamino)phenyl] methyl]-6-fluoro-1,4-dihydro-4-oxo-

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Technology Process of 1,8-Naphthyridine-3-carboxylic acid, 7-(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl-1-[[4-(dimethylamino)phenyl] methyl]-6-fluoro-1,4-dihydro-4-oxo-

There total 2 articles about 1,8-Naphthyridine-3-carboxylic acid, 7-(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl-1-[[4-(dimethylamino)phenyl] methyl]-6-fluoro-1,4-dihydro-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₂FN₅O₅

: 635308-46-2
7-((1S,4S)-2,5-diazabicyclo(2.2.1)hept-2-yl)-1-(4-(dimethylamino)benzyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 2h;

Reference yield:

: 10003-74-4,34403-52-6,140401-58-7
4-(dimethylamino)benzylamine dihydrochloride salt

: 99724-19-3,140629-77-2
3-(tert-butoxycarbonylamino)pyrrolidine

: 96568-05-7
2,6-dichloro-α-(ethoxymethylene)-5-fluoro-β-oxo-3-pyridinepropanoic acid ethyl ester

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 635308-46-2
7-((1S,4S)-2,5-diazabicyclo(2.2.1)hept-2-yl)-1-(4-(dimethylamino)benzyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: 4-(dimethylamino)benzylamine dihydrochloride salt; 2,6-dichloro-α-(ethoxymethylene)-5-fluoro-β-oxo-3-pyridinepropanoic acid ethyl ester; With potassium carbonate; In acetonitrile; at 25 - 50 ℃; for 18h;

3-(tert-butoxycarbonylamino)pyrrolidine; In acetonitrile; at 85 ℃; for 48h;

(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester; With sodium hydroxide; water; more than 3 stages;